Тест 180.
Секвениране (WES) и интерпретация на клиничен екзом
Характеристика на теста: (включва 5 227 гени)
Човешкият геном съдържа около 20 000 гени, близо 6 000 от които са свързани със заболяване или клиничен фенотип.
Генният панел включва 5 227 клинично значими гени (96%) и е най-големият секвенционен панел, наличен до момента. Прицелните геномни райони са подбрани от международните база данни: the Human Mutation Database (HGMD), the Online Mendelian Inheritance in Man (OMIM), the GeneTests.org и др.
Панелът включва над 125395, 80-мерни сонди, всяка от които е подбрана спрямо човешкия референтен геном (GRCh38). Сондите са така проектирани, че обхващат всички 62 000 екзони и екзонни-интрон граници (около 20 bp) на прицелните 5 227 гени. Постига се покритие от поне 20х за 95% от прицелните райони.
Основание за насочване:
Секвенционният панел включва гени, асоциирани с всички заболявания, известни до момента и е приложим за диагностика на пациенти с неясна диагноза и/или сложен клиничен фенотип. Подходящи за този панел са и пациенти, при които не са открити патогенни варианти след директно и/или новогенерационно секвениране на гени/генни райони, включени в по-тясните секвенционни панели.
Интерпретиране на резултатите:
Установяването на точкови мутации и малки делеции/инсерции в гените от панела ще позволи поставянето на генетична диагноза.
Наличие на големи делеции и инсерции не може да бъде установено с този метод. За установяването на такива се препоръчва комбинация с подходящ анализ за CNV (MLPA, aCGH).
Генетичният консултант ще интерпретира и отговори на всички въпроси относно резултата Ви.
Метод: Новогенерационно секвениране
Методът включва двупосочно ДНК секвениране на всички кодиращи екзони и интрон-екзонни граници на прицелните гени. Лабораторията предлага Сангер-секвениране на единичен екзон или двойка екзони при родственици на пациента за определяне на носителския статус в случаите, когато мутацията е известна (Тест № 182).
Чувствителност на метода: > 98%; зависи от съдържанието на GC и АТ, както и от наличието на сегментно дуплицирани гени.
Какво включва тестът?
Изолиране на ДНК и съхраняване на пробата.
Паралелно секвениране на прицелните гени.
Биоинформатичен анализ на секвенционните данни. За всеки пациент се анализират само данните за гена(ите) от интерес.
Оформяне на писмен резултат от генетичния тест.
Диагностична интерпретация на резултатите и генетично консултиране.
Биологичния материал: Венозна кръв или ДНК
За повече информация, моля прочете внимателно „Изисквания към биологичния материал и информация за транспортиране“.
A2M, A2ML1, A4GALT, AAAS, AAGAB, AANAT, AARS, AARS2, AASS, ABAT, ABCA1, ABCA12, ABCA3, ABCA4, ABCA5, ABCA7, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD3, ABCD4, ABCG1, ABCG2, ABCG5, ABCG8, ABHD12, ABHD5, ABL1, ABR, ACACA, ACAD8, ACAD9, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAN, ACAT1, ACAT2, ACBD3, ACBD5, ACBD6, ACD, ACE, ACE2, ACHE, ACIN1, ACKR1, ACO2, ACOT9, ACOX1, ACOX2, ACP2, ACP5, ACPT, ACSF3, ACSL4, ACSL6, ACTA1, ACTA2, ACTB, ACTC1, ACTG1, ACTG2, ACTL6A, ACTL6B, ACTN1, ACTN2, ACTN4, ACVR1, ACVR1B, ACVR2B, ACVRL1, ACY1, ADA, ADAM10, ADAM17, ADAM9, ADAMTS10, ADAMTS13, ADAMTS17, ADAMTS18, ADAMTS2, ADAMTSL2, ADAMTSL4, ADAR, ADAT3, ADCK3, ADCK4, ADCY1, ADCY10, ADCY5, ADCY6, ADD1, ADD2, ADD3, ADGRA3, ADGRG1, ADGRG4, ADGRG6, ADGRV1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ADI1, ADIPOQ, ADIPOR1, ADIPOR2, ADK, ADM, ADNP, ADORA2A, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, ADSL, AFF1, AFF2, AFF3, AFF4, AFG3L2, AFP, AGA, AGBL1, AGBL5, AGGF1, AGK, AGL, AGO1, AGPAT2, AGPS, AGRN, AGRP, AGT, AGTR1, AGTR2, AGXT, AHCY, AHDC1, AHI1, AHNAK, AHNAK2, AHR, AHSP, AICDA, AIFM1, AIMP1, AIP, AIPL1, AIRE, AK1, AK2, AKAP10, AKAP17A*, AKAP4, AKAP9, AKR1B1, AKR1C2, AKR1C4, AKR1D1, AKR1E2, AKT1, AKT2, AKT3, ALAD, ALAS1, ALAS2, ALB, ALDH18A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH8A1, ALDH9A1, ALDOA, ALDOB, ALG1, ALG10, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, ALK, ALLC, ALMS1, ALOX12B, ALOX5, ALOXE3, ALPK3, ALPL, ALS2, ALX1, ALX3, ALX4, AMACR, AMBN, AMELX, AMER1, AMH, AMHR2, AMMECR1, AMN, AMPD1, AMPD2, AMPD3, AMT, AMTN, ANG, ANGPT2, ANGPTL3, ANGPTL4, ANK1, ANK2, ANK3, ANKH, ANKLE2, ANKRD1, ANKRD11, ANKRD26, ANKRD34A, ANKRD35, ANKRD55, ANKS3, ANKS6, ANLN, ANO10, ANO3, ANO5, ANO6, ANOS1, ANTXR1, ANTXR2, ANXA11, ANXA5, AOX1, AP1S1, AP1S2, AP1S3, AP2S1, AP3B1, AP3D1, AP4B1, 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ATP5O, ATP5S, ATP5SL, ATP6AP1, ATP6AP2, ATP6V0A2, ATP6V0A4, ATP6V1B1, ATP6V1B2, ATP7A, ATP7B, ATP8A2, ATP8B1, ATPAF1, ATPAF2, ATPIF1, ATR, ATRIP, ATRX, ATXN1, ATXN10, ATXN2, ATXN3, ATXN3L, ATXN7, AUH, AURKC, AUTS2, AVP, AVPR1A, AVPR2, AWAT2, AXIN1, AXIN2, AXL, B2M, B3GALNT1, B3GALNT2, B3GALT6, B3GAT3, B3GLCT, B3GNT2, B4GALNT1, B4GALT1, B4GALT7, B4GAT1, B9D1, B9D2, BAAT, BACH2, BAG3, BANF1, BANK1, BAP1, BARD1, BARHL1, BAZ1B, BBIP1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BCAM, BCAN, BCAP31, BCAT1, BCAT2, BCHE, BCKDHA, BCKDHB, BCKDK, BCL10, BCL11A, BCL2, BCL6, BCO1, BCOR, BCORL1, BCR, BCS1L, BDNF, BDP1, BEAN1, BEST1, BFSP1, BFSP2, BGN, BHLHA9, BHLHE41, BICC1, BICD2, BIN1, BIRC3, BLK, BLM, BLMH, BLNK, BLOC1S3, BLOC1S5, BLOC1S6, BLVRA, BMP1, BMP15, BMP2, BMP4, BMP5, BMP6, BMP7, BMPER, BMPR1A, BMPR1B, BMPR2, BMS1, BNC2, BOLA1, BOLA2, BOLA3, BPGM, BPIFA3, BPIFB6, BRAF, BRAT1, BRCA1, BRCA2, BRCC3, BRD4, BRF1, BRIP1, BRPF1, BRWD3, BSCL2, BSG, BSN, BSND, BTD, BTK, BTRC, BUB1, BUB1B, BUB3, BVES, BZRAP1, C10orf11, C10orf2, C11orf95, C12orf57, C12orf65, C15orf41, C17orf89, C19orf12, C1D, C1GALT1C1, C1QA, C1QB, C1QC, C1QTNF5, C1R, C1S, C2, C21orf2, C21orf59, C22orf23, C2CD2, C2CD3, C2orf71, C3, C4A, C4B, C4BPA, C4orf26, C5, C5orf42, C6, C7, C7orf43, C8A, C8B, C8G, C8orf37, C9, C9orf72, CA12, CA2, CA4, CA5A, CA8, CABIN1, CABP2, CABP4, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1S, CACNA2D1, CACNA2D4, CACNB2, CACNB4, CACNG2, CAD, CALCR, CALCRL, CALM1, CALM2, CALM3, CALR, CALR3, CAMK2A, CAMK2G, CAMKMT, CAMTA1, CANT1, CAP1, CAPN1, CAPN10, CAPN15, CAPN3, CAPN5, CAPRIN1, CARD11, CARD14, CARD9, CARS, CARS2, CARTPT, CASC5, CASK, CASP10, CASP2, CASP3, CASP8, CASQ1, CASQ2, CASR, CAST, CAT, CATSPER1, CATSPER2, CAV1, CAV3, CBFA2T3, CBFB, CBL, CBR1, CBR3, CBS, CBX2, CC2D1A, CC2D2A, CCBE1, CCDC103, CCDC114, CCDC115, CCDC151, CCDC174, CCDC22, CCDC23, CCDC28B, CCDC39, CCDC40, CCDC42B, CCDC50, CCDC6, CCDC65, CCDC69, CCDC78, CCDC8, CCDC88C, CCL11, CCL2, CCL3, CCM2, CCNA2, CCNB3, CCND1, CCND2, CCNO, CCR1, CCR5, CCR6, CCT5, CD109, CD151, CD164, CD177, CD19, CD207, CD209, CD244, CD247, CD27, CD28, CD2AP, CD320, CD36, CD3D, CD3E, CD3EAP, CD3G, CD4, CD40, CD40LG, CD44, CD46, CD55, CD59, CD79A, CD79B, CD81, CD82, CD83, CD8A, CD96, CD99*, CDA, CDAN1, CDC14A, CDC20, CDC42, CDC45, CDC5L, CDC6, CDC73, CDCA7, CDH1, CDH15, CDH23, CDH3, CDHR1, CDK13, CDK16, CDK4, CDK5, CDK5RAP2, CDK6, CDK8, CDKAL1, CDKL5, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CDON, CDSN, CDT1, CEACAM16, CEBPA, CEBPE, CECR1, CEL, CELF6, CELSR1, CELSR2, CENPE, CENPF, CENPJ, CEP104, CEP120, CEP126, CEP135, CEP152, CEP164, CEP19, CEP250, CEP290, CEP41, CEP57, CEP63, CEP78, CEP83, CEP89, CERKL, CERS1, CERS3, CES1, CES2, CETP, CFAP44, CFAP47, CFAP52, CFAP53, CFAP97, CFB, CFC1, CFD, CFH, CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, CFI, CFL1, CFL2, CFP, CFTR, CHAMP1, CHAT, CHCHD10, CHCHD2, CHD1, CHD1L, CHD2, CHD4, CHD7, CHD8, CHEK2, CHGA, CHGB, CHI3L1, CHIT1, CHKB, CHL1, CHM, CHMP1A, CHMP2B, CHMP4B, CHN1, CHRDL1, CHRM3, CHRNA1, CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNA9, CHRNB1, CHRNB2, CHRND, CHRNE, CHRNG, CHST1, CHST10, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9, CHSY1, CHUK, CIB2, CIC, CIDEC, CIITA, CILP, CISD2, CISH, CITED2, CIZ1, CKAP2L, CKB, CLCA2, CLCA4, CLCF1, CLCN1, CLCN2, CLCN4, CLCN5, CLCN7, CLCNKA, CLCNKB, CLDN1, CLDN11, CLDN14, CLDN16, CLDN19, CLDN9, CLEC4M, CLEC7A, CLIC2, CLIC5, CLIP1, CLIP2, CLMP, CLN3, CLN5, CLN6, CLN8, CLNS1A, CLP1, CLPB, CLPP, CLPS, CLRN1, CLTC, CLTCL1, CMC4, CNBP, CNDP1, CNGA1, CNGA2, CNGA3, CNGB1, CNGB3, CNKSR1, CNKSR2, CNNM2, CNNM4, CNOT3, CNTN1, CNTN2, CNTN4, CNTNAP1, CNTNAP2, COA1, COA3, COA5, COA6, COASY, COCH, COG1, COG2, COG4, COG5, COG6, COG7, COG8, COL10A1, COL11A1, COL11A2, COL12A1, COL13A1, COL14A1, COL17A1, COL18A1, COL1A1, COL1A2, COL25A1, COL27A1, COL2A1, COL3A1, COL4A1, COL4A2, COL4A3, COL4A3BP, COL4A4, COL4A5, COL4A6, COL5A1, COL5A2, COL6A1, COL6A2, COL6A3, COL7A1, COL8A2, COL9A1, COL9A2, COL9A3, COLEC11, COLQ, COMP, COMT, COPA, COQ10A, COQ10B, COQ2, COQ3, COQ4, COQ5, COQ6, COQ7, COQ9, CORIN, CORO1A, COX10, COX14, COX15, COX20, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CP, CPA1, CPA6, CPB1, CPLX1, CPN1, CPOX, CPS1, CPT1A, CPT1B, CPT1C, CPT2, CPXCR1, CR1, CR2, CRADD, CRAT, CRB1, CRB2, CRBN, CREB1, CREB3L1, CREB3L2, CREB3L3, CREBBP, CRELD1, CRH, CRIPT, CRKL, CRLF1, CRLF2*, CROT, CRTAP, CRX, CRYAA, CRYAB, CRYBA1, CRYBA2, CRYBA4, CRYBB1, CRYBB2, CRYBB3, CRYGA, CRYGB, CRYGC, CRYGD, CRYGS, CRYM, CSF1R, CSF2RA, CSF2RB, CSF3R, CSNK1D, CSNK1G1, CSNK2A1, CSPP1, CSRP3, CST3, CSTA, CSTB, CSTF2, CTBP1, CTC1, CTCF, CTDP1, CTDSP2, CTF1, CTGF, CTH, CTHRC1, CTLA4, CTNNA1, CTNNA3, CTNNB1, CTNND2, CTNS, CTPS1, CTPS2, CTRC, CTSA, CTSC, CTSD, CTSF, CTSH, CTSK, CTTNBP2, CUBN, CUL3, CUL4B, CUL7, CUX2, CWF19L1, CX3CR1, CXCL10, CXCL12, CXCL8, CXCR1, CXCR2, CXCR4, CXorf58, CYB5A, CYB5R1, CYB5R2, CYB5R3, CYB5R4, CYB5RL, CYBA, CYBB, CYC1, CYCS, CYLD, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP20A1, CYP21A2, CYP24A1, CYP26A1, CYP26B1, CYP26C1, CYP27A1, CYP27B1, CYP2A13, CYP2A6, CYP2A7, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2D7P, CYP2E1, CYP2F1, CYP2J2, CYP2R1, CYP2S1, CYP2U1, CYP39A1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP46A1, CYP4A11, CYP4B1, CYP4F11, CYP4F12, CYP4F2, CYP4F22, CYP4F3, CYP4F8, CYP4V2, CYP4Z1, CYP51A1, CYP7A1, CYP7B1, CYP8B1, D2HGDH, DAB2, DACT1, DAG1, DAO, DAOA, DARS, DARS2, DAW1, DBH, DBT, DCAF17, DCAF8, DCC, DCDC2, DCHS1, DCHS2, DCLRE1B, DCLRE1C, DCN, DCPS, DCTN1, DCTN4, DCX, DCXR, DDB1, DDB2, DDC, DDHD1, DDHD2, DDIT3, DDO, DDOST, DDR1, DDR2, DDX11, DDX26B, DDX39A, DDX3X, DDX41, DDX53, DDX58, DDX59, DEAF1, DECR1, DEK, DENND5A, DEPDC5, DES, DFNA5, DFNB59, DGAT1, DGCR14, DGCR2, DGCR6, DGCR8, DGKE, DGKH, DGKQ, DGUOK, DHCR24, DHCR7, DHDDS, DHFR, DHFRL1, DHH, DHODH, DHRS1, DHRS12, DHRS13, DHRS2, DHRS3, DHRS4, DHRS4L1, DHRS4L2, DHRS7, DHRS7B, DHRS7C, DHRS9, DHRSX, DHTKD1, DHX30, DHX38, DIABLO, DIAPH1, DIAPH2, DIAPH3, DICER1, DIO2, DIO3, DIP2B, DIRC2, DIS3L2, DISC1, DISP1, DKC1, DKK1, DLAT, DLC1, DLD, DLEC1, DLG1, DLG2, DLG3, DLG4, DLK1, DLL1, DLL3, DLL4, DLST, DLX2, DLX3, DLX4, DLX5, DLX6, DMD, DMGDH, DMP1, DMPK, DMRT1, DMTF1, DMTN, DMXL2, DNA2, DNAAF1, DNAAF2, DNAAF3, DNAAF5, DNAH1, DNAH11, DNAH2, DNAH5, DNAH6, DNAH8, DNAH9, DNAI1, DNAI2, DNAJB1, DNAJB13, DNAJB2, DNAJB6, DNAJC13, DNAJC19, DNAJC21, DNAJC3, DNAJC5, DNAJC6, DNAL1, DNAL4, DNASE1, DNASE1L3, DNM1, DNM1L, DNM2, DNMT1, DNMT3A, DNMT3B, DOCK11, DOCK2, DOCK6, DOCK7, DOCK8, DOK7, DOLK, DOLPP1, DPAGT1, DPCR1, DPEP1, DPF1, DPF2, DPF3, DPH1, DPM1, DPM2, DPM3, DPP10, DPP6, DPP9, DPY19L2, DPYD, DPYS, DRAM2, DRC1, DRD2, DRD3, DRD4, DRD5, DRP2, DSC1, DSC2, DSC3, DSE, DSG1, DSG2, DSG4, DSP, DSPP, DST, DSTYK, DTD1, DTHD1, DTNA, DTNBP1, DUOX1, DUOX2, DUOXA2, DUS2, DUSP6, DVL1, DVL2, DVL3, DYM, DYNC1H1, DYNC2H1, DYNC2LI1, DYRK1A, DYRK1B, DYSF, DYX1C1, E2F1, E2F3, EARS2, EBF3, EBP, ECE1, ECEL1, ECHS1, ECM1, ECSIT, EDA, EDA2R, EDAR, EDARADD, EDC3, EDN1, EDN3, EDNRA, EDNRB, EEF1A2, EEF1B2, EEF2, EFCAB13, EFEMP1, EFEMP2, EFHC1, EFNA4, EFNB1, EFTUD2, EGF, EGFR, EGLN1, EGLN2, EGLN3, EGR2, EHBP1, EHHADH, EHMT1, EIF1AX, EIF2AK3, EIF2AK4, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S2, EIF2S3, EIF4A3, EIF4E, EIF4ENIF1, EIF4G1, EIF4G2, ELAC2, ELANE, ELF4, ELK1, ELL, ELMOD2, ELMOD3, ELN, ELOVL4, ELOVL5, ELP2, ELP4, EMC1, EMD, EMG1, EML1, EML4, EMP2, EMX2, EN2, ENAM, ENG, ENKD1, ENKUR, ENO1, ENO3, ENOX2, ENPP1, ENPP3, ENTHD2, ENTPD1, EOGT, EOMES, EP300, EPAS1, EPB41, EPB41L1, EPB42, EPCAM, EPG5, EPHA2, EPHA4, EPHB1, EPHB2, EPHB3, EPHB4, EPHX1, EPHX2, EPM2A, EPO, EPOR, EPPK1, EPRS, EPS8, EPS8L3, EPX, ERAP1, ERBB2, ERBB3, ERBB4, ERC1, ERC2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L2, ERCC8, ERF, ERG, ERLIN1, ERLIN2, ERMAP, ERMARD, ESCO2, ESPN, ESR1, ESR2, ESRRB, ESX1, ETF1, ETFA, ETFB, ETFDH, ETHE1, ETV1, ETV4, ETV6, EVC, EVC2, EWSR1, EXOSC3, EXOSC8, EXPH5, EXT1, EXT2, EYA1, EYA4, EYS, EZH2, EZR, F10, F11, F12, F13A1, F13B, F2, F5, F7, F8, F9, FA2H, FAAH, FAAH2, FABP4, FADD, FADS2, FAF1, FAH, FAM111A, FAM111B, FAM120C, FAM124B, FAM126A, FAM134B, FAM13A, FAM161A, FAM198B, FAM20A, FAM20C, FAM47B, FAM58A, FAM65B, FAM83H, FAN1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAR1, FARS2, FAS, FASLG, FASN, FASTKD2, FAT1, FAT4, FBF1, FBLN1, FBLN5, FBN1, FBN2, FBP1, FBP2, FBXL4, FBXO2, FBXO25, FBXO31, FBXO38, FBXO7, FBXW4, FCGR1A, FCGR2A, FCGR2B, FCGR3A, FCGR3B, FCGRT, FCN1, FCN2, FCN3, FCRL6, FDPS, FDX1, FDX1L, FECH, FERMT1, FERMT3, FEZF1, FFAR4, FGA, FGB, FGD1, FGD4, FGF10, FGF12, FGF14, FGF16, FGF17, FGF20, FGF23, FGF3, FGF5, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFRL1, FGG, FH, FHIT, FHL1, FHL2, FIG4, FIGLA, FIGN, FIP1L1, FKBP10, FKBP14, FKBP5, FKBPL, FKRP, FKTN, FLAD1, FLCN, FLG, FLI1, FLII, FLNA, FLNB, FLNC, FLRT1, FLRT3, FLT3, FLT4, FLVCR1, FLVCR2, FMN1, FMN2, FMO1, FMO2, FMO3, FMO4, FMO5, FMO6P, FMR1, FN1, FNBP4, FNIP1, FOLR1, FOLR2, FOLR3, FOS, FOXA1, FOXC1, FOXC2, FOXD2, FOXD3, FOXE1, FOXE3, FOXF1, FOXF2, FOXG1, FOXH1, FOXI1, FOXI3, FOXL1, FOXL2, FOXN1, FOXN2, FOXO1, FOXO4, FOXP1, FOXP2, FOXP3, FOXRED1, FPR1, FRAS1, FREM1, FREM2, FRG1, FRMD4A, FRMD7, FRMPD4, FRRS1L, FRS2, FRY, FRZB, FSCN2, FSHB, FSHR, FTCD, FTH1, FTL, FTO, FTSJ1, FUCA1, FUS, FUT1, FUT2, FUT6, FUZ, FXN, FXYD2, FYCO1, FZD2, FZD3, FZD4, FZD5, FZD6, FZR1, G6PC, G6PC3, G6PD, GAA, GAB3, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GABRR3, GAD1, GAL, GALC, GALE, GALK1, GALNS, GALNT11, GALNT12, GALNT3, GALT, GAMT, GAN, GAPDH, GARS, GAS1, GAS8, GATA1, GATA2, GATA3, GATA4, GATA5, GATA6, GATAD1, GATAD2B, GATB, GATC, GATM, GBA, GBA2, GBE1, GBP2, GBX2, GCDH, GCGR, GCH1, GCK, GCKR, GCLC, GCLM, GCM2, GCNT2, GCSH, GDAP1, GDF1, GDF2, GDF3, GDF5, GDF6, GDI1, GDNF, GFAP, GFER, GFI1, GFI1B, GFM1, GFM2, GFPT1, GFRA1, GGCX, GGH, GGT1, GH1, GHR, GHRHR, GHRL, GHSR, GIF, GIGYF2, GIPC2, GIPC3, GJA1, GJA3, GJA5, GJA8, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJC2, GJC3, GJE1, GK, GK2, GLA, GLB1, GLCCI1, GLDC, GLDN, GLE1, GLI1, GLI2, GLI3, GLIS2, GLIS3, GLMN, GLP1R, GLRA1, GLRA2, GLRB, GLRX5, GLS, GLS2, GLUD1, GLUL, GLYCTK, GM2A, GMNN, GMPPA, GMPPB, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAS, GNAT1, GNAT2, GNB1, GNB3, GNB4, GNE, GNMT, GNPAT, GNPTAB, GNPTG, GNRH1, GNRHR, GNS, GOLGA5, GON4L, GORAB, GOSR2, GOT1, GP1BA, GP1BB, GP6, GP9, GPC1, GPC3, GPC4, GPC6, GPD1, GPD1L, GPHN, GPI, GPIHBP1, GPR101, GPR143, GPR161, GPR179, GPR180, GPR35, GPR88, GPRASP1, GPRIN1, GPRIN2, GPSM2, GPT2, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GRAMD1B, GRB14, GREM1, GREM2, GRHL2, GRHL3, GRHPR, GRIA1, GRIA2, GRIA3, GRID1, GRID2, GRIK2, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIP1, GRK1, GRM1, GRM3, GRM6, GRM7, GRN, GRXCR1, GRXCR2, GSC, GSKIP, GSN, GSPT2, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTCD, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO1, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, GTF2E2, GTF2H5, GTF2I, GTF2IRD1, GTPBP3, GTPBP8, GUCA1A, GUCA1B, GUCY1A3, GUCY2C, GUCY2D, GUSB, GYG1, GYG2, GYPA, GYPB, GYPC, GYS1, GYS2, H6PD, HABP2, HACD1, HACE1, HADH, HADHA, HADHB, HAGH, HAL, HAMP, HAND2, HARS, HARS2, HAUS7, HAVCR1, HAX1, HBA1, HBA2, HBB, HBD, HBE1, HBG1, HBG2, HBM, HBQ1, HBZ, HCCS, HCFC1, HCN1, HCN3, HCN4, HCRT, HDAC4, HDAC5, HDAC6, HDAC8, HDAC9, HDC, HDHD1, HECW2, HELLS, HEPACAM, HEPH, HERC1, HERC2, HES1, HES5, HES7, HESX1, HEXA, HEXB, HFE, HFE2, HFM1, HGD, HGF, HGSNAT, HHAT, HIBCH, HIC1, HIF1A, HIF1AN, HIF3A, HIKESHI, HINT1, HIRA, HIST1H4B, HIST3H3, HIVEP2, HK1, HK2, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLCS, HLF, HMBS, HMCN1, HMGA2, HMGB3, HMGCL, HMGCS2, HMMR, HMOX1, HMX1, HMX2, HMX3, HNF1A, HNF1B, HNF4A, HNMT, HNRNPA1, HNRNPA2B1, HNRNPDL, HNRNPH1, HNRNPK, HNRNPU, HNRPH2, HOGA1, HOMER2, HOOK1, HOXA1, HOXA11, HOXA13, HOXA2, HOXB1, HOXB13, HOXC13, HOXD1, HOXD10, HOXD13, HP, HPCA, HPD, HPGD, HPRT1, HPS1, HPS3, HPS4, HPS5, HPS6, HPSE2, HR, HRAS, HRG, HS6ST1, HS6ST2, HSD11B1, HSD11B2, HSD17B10, HSD17B11, HSD17B14, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD17B7P2, HSD3B1, HSD3B2, HSD3B7, HSF4, HSPA9, HSPB1, HSPB3, HSPB8, HSPBAP1, HSPD1, HSPG2, HTR1A, HTR2A, HTRA1, HTRA2, HTT, HUWE1, HYAL1, HYDIN, HYKK, HYLS1, IAPP, IARS2, IBA57, ICAM1, ICAM4, ICK, ICOS, IDH1, IDH2, IDH3B, IDS, IDUA, IER3IP1, IFIH1, IFITM3, IFITM5, IFNAR2, IFNG, IFNGR1, IFNGR2, IFNL3, IFNL4, IFRD1, IFT122, IFT140, IFT172, IFT27, IFT43, IFT46, IFT74, IFT80, IFT81, IFT88, IGBP1, IGF1, IGF1R, IGF2, IGF2BP2, IGF2R, IGFALS, IGFBP1, IGFBP3, IGFBP7, IGHG2, IGHM, IGHMBP2, IGKC, IGLL1, IGSF1, IGSF3, IHH, IKBKAP, IKBKB, IKBKG, IKZF1, IKZF3, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL17A, IL17D, IL17F, IL17RA, IL17RC, IL17RD, IL18, IL1B, IL1RAPL1, IL1RN, IL21, IL21R, IL23A, IL23R, IL27, IL2RA, IL2RB, IL2RG, IL31RA, IL36RN, IL3RA*, IL4R, IL6, IL6R, IL7R, ILDR1, ILK, IMPAD1, IMPDH1, IMPG1, IMPG2, INF2, ING1, INHA, INHBA, INPP4A, INPP5E, INPP5K, INPPL1, INS, INSL3, INSR, INVS, IPMK, IPPK, IQCB1, IQCE, IQSEC2, IRAK1, IRAK3, IRAK4, IRF1, IRF3, IRF4, IRF5, IRF6, IRF7, IRF8, IRGM, IRS1, IRS2, IRX4, IRX5, ISCA1, ISCA2, ISCU, ISG15, ISL1, ISPD, ITCH, ITGA10, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA6, ITGA7, ITGA8, ITGA9, ITGAM, ITGB1, ITGB2, ITGB3, ITGB4, ITGB6, ITIH4, ITIH6, ITK, ITM2B, ITPA, ITPKC, ITPR1, ITPR2, ITPR3, IVD, IYD, JAG1, JAG2, JAGN1, JAK1, JAK2, JAK3, JAM3, JAZF1, JMJD1C, JPH2, JPH3, JRK, JUN, JUP, KANK1, KANK2, KANSL1, KARS, KAT2B, KAT6A, KAT6B, KATNA1, KATNB1, KATNIP, KBTBD13, KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, KCNAB2, KCNB1, KCNC1, KCNC3, KCND1, KCND3, KCNE1, KCNE2, KCNE3, KCNE5, KCNH1, KCNH2, KCNH5, KCNJ1, KCNJ10, KCNJ11, KCNJ12, KCNJ13, KCNJ16, KCNJ18, KCNJ2, KCNJ5, KCNJ6, KCNJ8, KCNK12, KCNK18, KCNK3, KCNK9, KCNMA1, KCNMB1, KCNN1, KCNN4, KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNT1, KCNV2, KCTD1, KCTD11, KCTD17, KCTD7, KDM1A, KDM5A, KDM5B, KDM5C, KDM6A, KDM6B, KDR, KERA, KHDC3L, KHK, KHSRP, KIAA0196, KIAA0319, KIAA0319L, KIAA0586, KIAA1033, KIAA1199, KIAA1549, KIAA2022, KIDINS220, KIF11, KIF14, KIF1A, KIF1B, KIF1BP, KIF1C, KIF21A, KIF22, KIF23, KIF26A, KIF26B, KIF2A, KIF4A, KIF5A, KIF5C, KIF7, KIR3DL1, KIRREL3, KISS1, KISS1R, KIT, KITLG, KIZ, KL, KLC2, KLF1, KLF10, KLF11, KLF13, KLF6, KLF8, KLHDC8B, KLHL10, KLHL15, KLHL21, KLHL24, KLHL3, KLHL34, KLHL4, KLHL40, KLHL41, KLHL7, KLHL9, KLK1, KLK4, KLKB1, KLLN, KLRC4, KMT2A, KMT2B, KMT2C, KMT2D, KNG1, KPNA7, KPTN, KRAS, KRIT1, KRT1, KRT10, KRT12, KRT13, KRT14, KRT16, KRT17, KRT2, KRT25, KRT3, KRT4, KRT5, KRT6A, KRT6B, KRT6C, KRT71, KRT74, KRT75, KRT81, KRT83, KRT85, KRT86, KRT9, KYNU, L1CAM, L2HGDH, LACC1, LACTB, LAD1, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMC1, LAMC2, LAMC3, LAMP2, LAMTOR2, LARGE1, LARP7, LARS, LARS2, LAS1L, LBR, LCA5, LCAT, LCK, LCP1, LCT, LDB3, LDHA, LDHB, LDLR, LDLRAP1, LEF1, LEFTY2, LEMD3, LEP, LEPR, LETM1, LFNG, LGALS1, LGALS12, LGALS2, LGI1, LGR4, LHB, LHCGR, LHFPL3, LHFPL5, LHX1, LHX3, LHX4, LIAS, LIFR, LIG1, LIG4, LIM2, LIMK1, LIMS2, LIN28B, LINS, LINS1, LIPA, LIPC, LIPE, LIPH, LIPI, LIPN, LIPT1, LIPT2, LITAF, LIX1L, LMAN1, LMAN2L, LMBR1, LMBRD1, LMF1, LMNA, LMNB1, LMNB2, LMO1, LMO4, LMOD3, LMX1A, LMX1B, LONP1, LOR, LOXHD1, LOXL1, LOXL3, LPA, LPAR6, LPIN1, LPIN2, LPIN3, LPL, LRAT, LRBA, LRIG1, LRIG2, LRIG3, LRIT3, LRP1, LRP2, LRP4, LRP5, LRP6, LRP8, LRPAP1, LRPPRC, LRRC56, LRRC6, LRRC8A, LRRK1, LRRK2, LRSAM1, LRTOMT, LSS, LTA, LTBP2, LTBP3, LTBP4, LTC4S, LY6E, LYRM4, LYRM7, LYST, LYVE1, LYZ, LZTFL1, LZTR1, LZTS1, MAB21L2, MAD2L2, MAF, MAFB, MAG, MAGEA11, MAGEB1, MAGEB10, MAGEB2, MAGEC1, MAGEC3, MAGED1, MAGED2, MAGEE2, MAGEL2, MAGI1, MAGI2, MAGIX, MAGT1, MAK, MALT1, MAMLD1, MAN1B1, MAN2A1, MAN2B1, MAN2C1, MANBA, MAOA, MAOB, MAP1A, MAP2, MAP2K1, MAP2K2, MAP3K1, MAP3K13, MAP3K14, MAP3K15, MAP3K5, MAP3K6, MAP4K2, MAP7D3, MAPK1, MAPK10, MAPK13, MAPK15, MAPK8IP1, MAPKBP1, MAPRE2, MAPT, MARS, MARS2, MARVELD2, MASP1, MASP2, MASTL, MAT1A, MAT2A, MATN3, MATR3, MAX, MBD1, MBD5, MBL2, MBNL3, MBOAT7, MBTPS2, MC1R, MC2R, MC3R, MC4R, MCCC1, MCCC2, MCEE, MCF2, MCFD2, MCIDAS, MCM2, MCM4, MCM6, MCM8, MCM9, MCOLN1, MCOLN3, MCPH1, MCTP2, MCU, MDH2, MDM2, MECOM, MECP2, MECR, MED12, MED13, MED13L, MED17, MED23, MED25, MED9, MEF2A, MEF2C, MEFV, MEGF10, MEGF8, MEIS2, MEN1, MEOX1, MERTK, MESP2, MET, METAP1, METTL23, MFAP5, MFF, MFN2, MFRP, MFSD2A, MFSD6L, MFSD8, MGARP, MGAT2, MGAT5B, MGME1, MGMT, MGP, MGST1, MGST2, MGST3, MIB1, MICA, MICU1, MICU2, MID1, MID2, MIF, MINPP1, MIP, MIPEP, MIR17HG, MIR182, MIR183, MIR184, MIR204, MIR2861, MIR96, MITF, MKKS, MKL1, MKRN3, MKS1, MLC1, MLH1, MLH3, MLLT10, MLLT11, MLLT3, MLPH, MLTK, MLXIPL, MLYCD, MMAA, MMAB, MMACHC, MMADHC, MME, MMEL1, MMP1, MMP13, MMP14, MMP19, MMP2, MMP20, MMP21, MMP3, MMP9, MN1, MNS1, MNX1, MOB4, MOCOS, MOCS1, MOCS2, MOG, MOGAT2, MOGS, MORC2, MORC4, MOS, MPC1, MPDU1, MPDZ, MPI, MPL, MPLKIP, MPO, MPP3, MPV17, MPZ, MR1, MRAP, MRAP2, MRE11A, MRPL1, MRPL10, MRPL11, MRPL12, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL32, MRPL33, MRPL34, MRPL35, MRPL36, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL54, MRPL55, MRPL9, MRPS10, MRPS11, MRPS12, MRPS14, MRPS15, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS21, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MRRF, MS4A1, MS4A2, MSH2, MSH3, MSH6, MSL3, MSMB, MSMO1, MSN, MSR1, MSRA, MSRB3, MST1, MSTN, MSX1, MSX2, MT2A, MT3, MTAP, MTCH1, MTF1, MTFMT, MTHFD1, MTHFR, MTM1, MTMR1, MTMR14, MTMR2, MTMR8, MTNR1B, MTO1, MTOR, MTPAP, MTR, MTRR, MTSS1, MTTP, MUC1, MUC2, MUC5AC, MUC5B, MUC7, MURC, MUSK, MUT, MUTYH, MVD, MVK, MXI1, MXRA5, MYB, MYBPC1, MYBPC3, MYC, MYCN, MYD88, MYDGF, MYF6, MYH11, MYH14, MYH2, MYH3, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL3, MYL4, MYLIP, MYLK, MYLK2, MYO15A, MYO16, MYO18B, MYO1A, MYO1C, MYO1D, MYO1E, MYO1F, MYO1G, MYO3A, MYO5A, MYO5B, MYO6, MYO7A, MYO9B, MYOC, MYOM1, MYOM2, MYOT, MYOZ2, MYPN, MYT1L, NAA10, NAA15, NAB2, NABP1, NADK2, NAGA, NAGLU, NAGPA, NAGS, NAIP, NALCN, NANOS1, NANOS2, NANOS3, NARS, NARS2, NAT1, NAT2, NAT8, NAT8L, NAV2, NAXE, NBAS, NBEAL2, NBN, NCF1, NCF2, NCF4, NCOA2, NCOA4, NCR3, NCSTN, NDE1, NDN, NDNL2, NDP, NDRG1, NDST1, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NEB, NEBL, NECAB2, NECAP1, NECTIN1, NECTIN4, NEDD4L, NEFH, NEFL, NEK1, NEK2, NEK4, NEK8, NEK9, NELFA, NEU1, NEUROD1, NEUROG1, NEUROG3, NEXN, NF1, NF2, NFATC1, NFIA, NFIX, NFKB1, NFKB2, NFKBIA, NFS1, NFU1, NGF, NGLY1, NHEJ1, NHLRC1, NHP2, NHS, NIN, NIPA1, NIPA2, NIPAL1, NIPAL4, NIPBL, NKAP, NKX2-1, NKX2-2, NKX2-5, NKX2-6, NKX3-1, NKX3-2, NLGN2, NLGN3, NLGN4X, NLGN4Y, NLRC4, NLRP1, NLRP12, NLRP2, NLRP3, NLRP7, NME1, NME8, NMNAT1, NNMT, NNT, NOBOX, NOD2, NODAL, NOG, NOL3, NONO, NOP10, NOP56, NOS1, NOS1AP, NOS2, NOS3, NOSTRIN, NOTCH1, NOTCH2, NOTCH3, NOV, NOX1, NOX3, NOXO1, NPAP1, NPC1, NPC2, NPHP1, NPHP3, NPHP4, NPHS1, NPHS2, NPM1, NPPA, NPPC, NPR2, NPR3, NPRL2, NPRL3, NPSR1, NPTX2, NR0B1, NR0B2, NR1H4, NR1I2, NR1I3, NR2E3, NR2F1, NR2F2, NR3C1, NR3C2, NR4A2, NR4A3, NR5A1, NRAS, NRCAM, NRG1, NRK, NRL, NRTN, NRXN1, NRXN2, NRXN3, NSD1, NSDHL, NSMCE2, NSMCE3, NSMF, NSUN2, NT5C, NT5C2, NT5C3A, NT5E, NTF3, NTF4, NTHL1, NTM, NTN1, NTNG1, NTRK1, NTRK2, NTRK3, NUAK1, NUBPL, NUDT1, NUDT15, NUDT19, NUMA1, NUP107, NUP155, NUP188, NUP205, NUP214, NUP62, NUP93, NUTM1, NUTM2A, NUTM2B, NXF5, NYNRIN, NYX, OAS1, OAT, OBFC1, OBSCN, OBSL1, OC90, OCA2, OCLN, OCRL, ODF2L, OFD1, OGDH, OGG1, OGT, OLR1, OPA1, OPA3, OPHN1, OPLAH, OPN1LW, OPN1MW, OPN1SW, OPRD1, OPRK1, OPRM1, OPTN, OR13H1, OR2J3, OR5M1, ORAI1, ORC1, ORC4, ORC6, ORMDL3, OS9, OSBPL2, OSMR, OSTM1, OTC, OTOA, OTOF, OTOG, OTOGL, OTOP1, OTOR, OTX1, OTX2, OVOL2, OXA1L, OXCT1, OXTR, P2RX1, P2RX2, P2RY12, P2RY4, P2RY8, P3H1, P3H2, P4HA2, P4HB, PABPC4L, PABPC5, PABPN1, PACRG, PACS1, PADI4, PADI6, PAFAH1B1, PAH, PAK3, PALB2, PALLD, PAM16, PANK2, PAPPA2, PAPSS2, PARD3, PARK2, PARK7, PARN, PARP1, PARS2, PASD1, PASK, PAX1, PAX2, PAX3, PAX4, PAX5, PAX6, PAX7, PAX8, PAX9, PAXIP1, PBRM1, PBX1, PC, PCBD1, PCCA, PCCB, PCDH10, PCDH15, PCDH19, PCGF2, PCK1, PCK2, PCLO, PCM1, PCNA, PCNT, PCSK1, PCSK9, PCYT1A, PDAP1, PDCD10, PDCD6IP, PDE10A, PDE11A, PDE3A, PDE3B, PDE4D, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, PDE8B, PDGFB, PDGFD, PDGFRA, PDGFRB, PDGFRL, PDHA1, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDLIM3, PDLIM4, PDP1, PDP2, PDPK1, PDPR, PDSS1, PDSS2, PDX1, PDXK, PDYN, PDZD7, PECR, PEG3, PEPD, PER2, PER3, PET100, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX5L, PEX6, PEX7, PFKL, PFKM, PFN1, PGA3, PGAM1, PGAM2, PGAP1, PGAP2, PGAP3, PGD, PGK1, PGM1, PGM3, PGR, PGRMC1, PHACTR1, PHB, PHC1, PHEX, PHF10, PHF11, PHF21A, PHF6, PHF8, PHGDH, PHIP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PHOX2A, PHOX2B, PHYH, PHYKPL, PI4K2A, PI4KA, PIAS3, PIBF1, PICALM, PICK1, PIEZO1, PIEZO2, PIGA, PIGG, PIGL, PIGM, PIGN, PIGO, PIGQ, PIGT, PIGV, PIGW, PIGY, PIH1D3, PIK3C3, PIK3CA, PIK3CD, PIK3R1, PIK3R2, PIK3R5, PIKFYVE, PIN1, PIN4, PINK1, PIP4K2A, PIP5K1C, PIR, PITPNM3, PITRM1, PITX1, PITX2, PITX3, PJA1, PKD1, PKD2, PKHD1, PKHD1L1, PKLR, PKNOX1, PKP1, PKP2, PLA2G5, PLA2G6, PLA2G7, PLAC1, PLAG1, PLAGL1, PLAT, PLAU, PLCB1, PLCB4, PLCD1, PLCE1, PLCG2, PLCXD1*, PLCZ1, PLD3, PLEC, PLEKHA1, PLEKHG2, PLEKHG4, PLEKHG5, PLEKHM1, PLG, PLGLB1, PLIN1, PLK1, PLK4, PLN, PLOD1, PLOD2, PLOD3, PLP1, PLS3, PLXNA1, PLXNB3, PLXND1, PM20D1, PMEL, PML, PMM2, PMP22, PMPCA, PMS1, PMS2, PMVK, PNKD, PNKP, PNLIP, PNMT, PNOC, PNP, PNPLA1, PNPLA2, PNPLA6, PNPLA8, PNPO, PNPT1, POC1A, POC1B, PODXL, POF1B, POFUT1, POGLUT1, POGZ, POLA1, POLD1, POLE, POLG, POLG2, POLH, POLQ, POLR1A, POLR1C, POLR1D, POLR2D, POLR3A, POLR3B, POLR3GL, POMC, POMGNT1, POMGNT2, POMK, POMP, POMT1, POMT2, PON1, PON2, PON3, POP1, POR, PORCN, POT1, POU1F1, POU2AF1, POU3F4, POU4F3, POU6F2, PPA2, PPAPDC2, PPARA, PPARD, PPARG, PPARGC1A, PPARGC1B, PPIB, PPM1B, PPM1D, PPM1K, PPOX, PPP1CB, PPP1R15B, PPP1R17, PPP1R3A, PPP1R8, PPP2R1A, PPP2R1B, PPP2R2B, PPP2R5D, PPP6C, PPT1, PPY, PQBP1, PRB3, PRCC, PRCD, PRDM12, PRDM16, PRDM5, PRDM6, PRDM8, PRDX3, PRDX4, PRDX6, PREPL, PREX2, PRF1, PRG4, PRICKLE1, PRICKLE2, PRICKLE3, PRIMPOL, PRKACA, PRKACG, PRKAG2, PRKAR1A, PRKAR1B, PRKCD, PRKCG, PRKCH, PRKCSH, PRKD1, PRKD2, PRKDC, PRKG1, PRKRA, PRLR, PRM2, PRMT7, PRMT9, PRNP, PROC, PRODH, PROK2, PROKR2, PROM1, PROP1, PROS1, PROSC, PROX2, PROZ, PRPF3, PRPF31, PRPF4, PRPF6, PRPF8, PRPH, PRPH2, PRPS1, PRRG1, PRRG3, PRRT2, PRRX1, PRRX2, PRSS1, PRSS12, PRSS56, PRTN3, PRX, PSAP, PSAT1, PSEN1, PSEN2, PSENEN, PSMA3, PSMA6, PSMA7, PSMB4, PSMB8, PSMB9, PSMC3IP, PSMD10, PSPH, PSTK, PSTPIP1, PTCD1, PTCH1, PTCH2, PTCHD1, PTDSS1, PTEN, PTF1A, PTGDR, PTGER2, PTGIS, PTH, PTH1R, PTHLH, PTK2B, PTK7, PTPN1, PTPN11, PTPN12, PTPN14, PTPN18, PTPN2, PTPN21, PTPN22, PTPN23, PTPN3, PTPRC, PTPRD, PTPRF, PTPRO, PTPRQ, PTPRR, PTPRU, PTPRZ1, PTRF, PTRH1, PTRH2, PTS, PUF60, PURA, PUS1, PUS3, PVRL3, PXDN, PXMP2, PYCR1, PYCR2, PYDC1, PYGL, PYGM, PYROXD1, QARS, QDPR, QKI, QRICH1, QRSL1, RAB18, RAB23, RAB27A, RAB28, RAB33B, RAB38, RAB39B, RAB3GAP1, RAB3GAP2, RAB40AL, RAB7A, RABGGTA, RABL6, RAC1, RAC2, RAD21, RAD50, RAD51, RAD51A, RAD51B, RAD51C, RAD51D, RAD54B, RAD54L, RAF1, RAG1, RAG2, RAI1, RALGDS, RANBP2, RANGRF, RAP1A, RAP1B, RAPGEF1, RAPSN, RARA, RARB, RARG, RARS, RARS2, RASA1, RASA2, RASGRP2, RASSF1, RASSF8, RAX, RAX2, RB1, RB1CC1, RBBP8, RBCK1, RBM10, RBM15, RBM20, RBM28, RBM47, RBM8A, RBP3, RBP4, RBPJ, RCBTB1, RCC1L, RD3, RDH11, RDH12, RDH5, RDX, RECQL, RECQL4, REEP1, REEP2, REEP6, RELA, RELN, REN, RENBP, RERE, REST, RET, RETN, REV3L, RFC2, RFT1, RFX5, RFX6, RFXANK, RFXAP, RGAG1, RGL4, RGN, RGR, RGS5, RGS6, RGS7, RGS9, RGS9BP, RHAG, RHBDF2, RHCE, RHD, RHO, RHOD, RHOH, RIMS1, RIN2, RINT1, RIPK2, RIPK4, RIPPLY2, RIT1, RLBP1, RLIM, RMDN2, RMND1, RMRP, RNASE1, RNASE12, RNASE3, RNASEH1, RNASEH2A, RNASEH2B, RNASEH2C, RNASEL, RNASET2, RNF113A, RNF125, RNF128, RNF135, RNF139, RNF168, RNF170, RNF2, RNF213, RNF216, RNF31, RNF43, RNF6, RNF7, RNLS, RNPC3, RNU4ATAC, ROBO2, ROBO3, ROGDI, ROM1, ROR2, RORA, RORC, ROS1, RP1, RP1L1, RP2, RP9, RPE65, RPGR, RPGRIP1, RPGRIP1L, RPIA, RPL10, RPL10A, RPL11, RPL15, RPL19, RPL21, RPL26, RPL27, RPL34, RPL35A, RPL5, RPL9, RPN1, RPS10, RPS14, RPS15, RPS15A, RPS17, RPS19, RPS20, RPS24, RPS26, RPS27, RPS28, RPS29, RPS6KA3, RPS7, RPSA, RRAS, RRAS2, RRM1, RRM2B, RS1, RSC1A1, RSPH1, RSPH3, RSPH4A, RSPH9, RSPO1, RSPO4, RSPRY1, RTEL1, RTL1, RTN2, RTN3, RTN4IP1, RTN4R, RTTN, RUBCN, RUNX1, RUNX1T1, RUNX2, RUVBL2, RXFP2, RXRA, RYK, RYR1, RYR2, RYR3, S1PR2, SAA1, SACS, SAG, SALL1, SALL2, SALL4, SAMD9, SAMD9L, SAMHD1, SAR1B, SARDH, SARS, SARS2, SASH1, SASS6, SAT1, SATB2, SAV1, SBDS, SBF1, SBF2, SC5D, SCAPER, SCARB1, SCARB2, SCARF2, SCGB1D1, SCGB3A2, SCLT1, SCN10A, SCN11A, SCN1A, SCN1B, SCN2A, SCN2B, SCN3A, SCN3B, SCN4A, SCN4B, SCN5A, SCN8A, SCN9A, SCNN1A, SCNN1B, SCNN1G, SCO1, SCO2, SCP2, SCPEP1, SCRIB, SCYL1, SDC3, SDCCAG8, SDHA, SDHAF1, SDHAF2, SDHB, SDHC, SDHD, SDS, SEC14L2, SEC14L3, SEC16B, SEC23A, SEC23B, SEC24D, SEC61A1, SEC63, SECISBP2, SELE, SELP, SEMA3A, SEMA3C, SEMA3D, SEMA3E, SEMA4A, SEMA5A, SEMA7A, SEPN1, SEPSECS, SERAC1, SERPINA1, SERPINA2, SERPINA3, SERPINA5, SERPINA6, SERPINA7, SERPINB6, SERPINB7, SERPINB8, SERPINC1, SERPIND1, SERPINE1, SERPINF1, SERPINF2, SERPING1, SERPINH1, SERPINI1, SET, SETBP1, SETD1A, SETD2, SETD5, SETDB1, SETDB2, SETX, SF3B1, SF3B4, SFPQ, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD, SFXN4, SGCA, SGCB, SGCD, SGCE, SGCG, SGO1, SGSH, SH2B1, SH2B3, SH2D1A, SH3BP2, SH3D19, SH3PXD2B, SH3TC2, SHANK1, SHANK2, SHANK3, SHBG, SHFM1, SHH, SHOC2, SHOX*, SHOX2, SHPK, SHROOM2, SHROOM3, SHROOM4, SI, SIAE, SIGMAR1, SIK1, SIL1, SIM1, SIPA1L3, SIRT3, SIX1, SIX2, SIX3, SIX5, SIX6, SKI, SKIV2L, SLC10A1, SLC10A2, SLC11A1, SLC11A2, SLC12A1, SLC12A2, SLC12A3, SLC12A5, SLC12A6, SLC12A7, SLC13A1, SLC13A2, SLC13A3, SLC13A5, SLC14A1, SLC15A1, SLC15A2, SLC16A1, SLC16A12, SLC16A2, SLC16A9, SLC17A3, SLC17A5, SLC17A8, SLC17A9, SLC18A1, SLC18A2, SLC18A3, SLC19A1, SLC19A2, SLC19A3, SLC1A1, SLC1A3, SLC1A4, SLC20A2, SLC22A1, SLC22A10, SLC22A11, SLC22A12, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18, SLC22A18AS, SLC22A2, SLC22A3, SLC22A4, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC23A1, SLC23A2, SLC24A1, SLC24A4, SLC24A5, SLC25A1, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A17, SLC25A18, SLC25A19, SLC25A2, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A3, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A4, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46, SLC25A5, SLC25A53, SLC25A6*, SLC26A2, SLC26A3, SLC26A4, SLC26A5, SLC26A8, SLC26A9, SLC27A1, SLC27A4, SLC27A5, SLC28A1, SLC28A2, SLC28A3, SLC29A1, SLC29A2, SLC29A3, SLC2A1, SLC2A10, SLC2A2, SLC2A3, SLC2A4, SLC2A5, SLC2A6, SLC2A9, SLC30A10, SLC30A2, SLC30A4, SLC30A8, SLC31A1, SLC33A1, SLC34A1, SLC34A2, SLC34A3, SLC35A1, SLC35A2, SLC35A3, SLC35C1, SLC35D1, SLC36A2, SLC37A1, SLC37A4, SLC38A1, SLC38A8, SLC39A13, SLC39A14, SLC39A4, SLC39A5, SLC39A8, SLC3A1, SLC40A1, SLC41A1, SLC45A2, SLC46A1, SLC46A3, SLC4A1, SLC4A11, SLC4A4, SLC4A7, SLC52A1, SLC52A2, SLC52A3, SLC5A1, SLC5A2, SLC5A5, SLC5A6, SLC5A7, SLC6A1, SLC6A14, SLC6A17, SLC6A18, SLC6A19, SLC6A2, SLC6A20, SLC6A3, SLC6A4, SLC6A5, SLC6A6, SLC6A8, SLC6A9, SLC7A14, SLC7A5, SLC7A7, SLC7A8, SLC7A9, SLC8B1, SLC9A1, SLC9A3, SLC9A3R1, SLC9A6, SLC9A9, SLCO1A2, SLCO1B1, SLCO1B3, SLCO1C1, SLCO2A1, SLCO2B1, SLCO3A1, SLCO4A1, SLCO4C1, SLCO5A1, SLCO6A1, SLFN14, SLIT2, SLITRK1, SLITRK6, SLMAP, SLTM, SLURP1, SLX4, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMAD9, SMARCA2, SMARCA4, SMARCA5, SMARCAD1, SMARCAL1, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCD2, SMARCD3, SMARCE1, SMC1A, SMC3, SMCHD1, SMG9, SMIM1, SMN1*, SMN2*, SMO, SMOC1, SMOC2, SMOX, SMPD1, SMPX, SMS, SNAI2, SNAP25, SNAP29, SNCA, SNCAIP, SNCB, SNIP1, SNRNP200, SNRPB, SNRPE, SNRPN, SNTA1, SNTG1, SNX10, SNX14, SNX3, SNX31, SOAT1, SOBP, SOD1, SOD2, SOD3, SOHLH1, SON, SORD, SORL1, SORT1, SOS1, SOS2, SOST, SOX10, SOX11, SOX17, SOX18, SOX2, SOX3, SOX5, SOX9, SP110, SP7, SPAG1, SPAG17, SPAG6, SPARC, SPAST, SPATA16, SPATA5, SPATA7, SPECC1L, SPEF2, SPEG, SPG11, SPG20, SPG21, SPG7, SPIB, SPINK1, SPINK5, SPINT2, SPOP, SPP1, SPR, SPRED1, SPRTN, SPRY1, SPRY2, SPRY3, SPRY4, SPTA1, SPTAN1, SPTB, SPTBN2, SPTLC1, SPTLC2, SQSTM1, SRC, SRCAP, SRD5A2, SRD5A3, SREBF1, SREBF2, SRGAP1, SRGAP3, SRP72, SRPX2, SRRT, SRXN1, SRY, SS18, SS18L1, SSR4, SSX1, SSX2, ST14, ST3GAL3, ST3GAL4, ST3GAL5, ST6GAL2, STAB2, STAC3, STAG1, STAG3, STAMBP, STAR, STARD3, STARD4, STARD8, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STEAP3, STIL, STIM1, STIM2, STK11, STK19, STK4, STOM, STOX1, STRA6, STRADA, STRC, STS, STT3A, STT3B, STUB1, STX11, STX16, STX1A, STX1B, STX3, STXBP1, STXBP2, SUCLA2, SUCLG1, SUCLG2, SUFU, SUGCT, SULF1, SULT1A1, SULT1A2, SULT1A3*, SULT1B1, SULT1C2, SULT1C4, SULT1E1, SULT2A1, SULT2B1, SULT4A1, SUMF1, SUMO1, SUMO4, SUN1, SUN5, SUOX, SURF1, SUV420H1, SUZ12, SYCE1, SYCP2, SYCP3, SYN1, SYN2, SYNCRIP, SYNE1, SYNE2, SYNE4, SYNGAP1, SYNJ1, SYNJ2, SYNM, SYNPO, SYP, SYT1, SYT14, SYT2, SYTL2, SYTL4, SYTL5, SZT2, T, TAB2, TAC3, TACC1, TACC3, TACO1, TACR1, TACR3, TACSTD2, TAF1, TAF15, TAF2, TAF4B, TAF7L, TAL1, TAL2, TALDO1, TANC2, TANGO2, TAP1, TAP2, TAPBP, TAPT1, TARDBP, TARS2, TAS2R16, TAS2R38, TAT, TAZ, TBC1D1, TBC1D20, TBC1D24, TBC1D32, TBC1D4, TBC1D7, TBC1D8B, TBCD, TBCE, TBCK, TBK1, TBL1X, TBL1XR1, TBL2, TBP, TBR1, TBX1, TBX10, TBX15, TBX18, TBX19, TBX2, TBX20, TBX21, TBX22, TBX3, TBX4, TBX5, TBX6, TBXA2R, TBXAS1, TCAP, TCEAL3, TCF12, TCF20, TCF21, TCF3, TCF4, TCF7L1, TCF7L2, TCHH, TCIRG1, TCL1A, TCN1, TCN2, TCOF1, TCP10L2, TCTEX1D2, TCTN1, TCTN2, TCTN3, TDGF1, TDO2, TDP1, TDP2, TDRD7, TEAD1, TECPR2, TECR, TECTA, TEK, TELO2, TENM1, TENM3, TENM4, TERC, TERF2IP, TERT, TET2, TEX11, TEX28*, TF, TFAP2A, TFAP2B, TFB1M, TFE3, TFEB, TFG, TFR2, TFRC, TG, TGDS, TGFA, TGFB1, TGFB2, TGFB3, TGFBI, TGFBR1, TGFBR2, TGFBR3, TGFBRAP1, TGIF1, TGM1, TGM3, TGM5, TGM6, TH, THAP1, THBD, THBS1, THBS2, THG1L, THOC2, THOC6, THPO, THRA, THRB, THUMPD1, TIA1, TICAM1, TIMM44, TIMM8A, TIMP1, TIMP3, TINAGL1, TINF2, TIRAP, TJP1, TJP2, TK2, TKT, TKTL1, TLE6, TLL1, TLR1, TLR2, TLR3, TLR4, TLR5, TLR8, TLX1, TLX3, TM4SF20, TMC1, TMC6, TMC8, TMCO1, TMEM107, TMEM114, TMEM126A, TMEM126B, TMEM127, TMEM132E, TMEM135, TMEM138, TMEM165, TMEM173, TMEM185A, TMEM186, TMEM199, TMEM216, TMEM231, TMEM237, TMEM240, TMEM26, TMEM38B, TMEM43, TMEM5, TMEM67, TMEM70, TMEM98, TMIE, TMLHE, TMOD1, TMPO, TMPRSS15, TMPRSS3, TMPRSS4, TMPRSS5, TMPRSS6, TMTC3, TMX3, TNC, TNF, TNFAIP3, TNFRSF10B, TNFRSF11A, TNFRSF11B, TNFRSF13B, TNFRSF13C, TNFRSF1A, TNFRSF1B, TNFRSF4, TNFSF11, TNFSF12, TNFSF15, TNFSF4, TNIK, TNK2, TNKS2, TNNC1, TNNI2, TNNI3, TNNI3K, TNNT1, TNNT2, TNNT3, TNPO1, TNPO2, TNPO3, TNR, TNXB, TOMM34, TOP2A, TOPORS, TOR1A, TOR1AIP1, TOX4, TP53, TP63, TP73, TPCN2, TPH2, TPI1, TPK1, TPM1, TPM2, TPM3, TPM4, TPMT, TPO, TPP1, TPP2, TPRN, TRAC, TRAF3, TRAF3IP1, TRAF3IP2, TRAF6, TRAIP, TRAP1, TRAPPC11, TRAPPC2, TRAPPC9, TRDN, TREH, TREM2, TREX1, TREX2, TRH, TRHR, TRIAP1, TRIM2, TRIM24, TRIM27, TRIM32, TRIM33, TRIM37, TRIM44, TRIM54, TRIM63, TRIO, TRIOBP, TRIP11, TRIP4, TRIT1, TRMT1, TRMT10A, TRMT10C, TRMT2B, TRMT5, TRMU, TRNT1, TRPA1, TRPC3, TRPC6, TRPM1, TRPM3, TRPM4, TRPM6, TRPM7, TRPS1, TRPV3, TRPV4, TSC1, TSC2, TSC22D3, TSEN15, TSEN2, TSEN34, TSEN54, TSFM, TSG101, TSHB, TSHR, TSHZ1, TSHZ3, TSPAN12, TSPAN7, TSPEAR, TSPO, TSPYL1, TSR2, TTBK2, TTC12, TTC19, TTC21B, TTC25, TTC37, TTC7A, TTC8, TTF1, TTF2, TTI2, TTLL10, TTLL5, TTN, TTPA, TTR, TUB, TUBA1A, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB8, TUBG1, TUBGCP4, TUBGCP6, TUFM, TUFT1, TULP1, TUSC3, TWF1, TWIST1, TWIST2, TWSG1, TXN2, TXNIP, TXNL4A, TXNRD2, TYK2, TYMP, TYMS, TYR, TYROBP, TYRP1, UBA1, UBA2, UBA5, UBAC2, UBB, UBE2A, UBE2T, UBE3A, UBE3B, UBIAD1, UBQLN2, UBR1, UBR4, UBR7, UBTF, UCHL1, UCN, UCP1, UCP2, UCP3, UFD1L, UFSP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UGT8, UMOD, UMPS, UNC119, UNC13A, UNC13B, UNC13D, UNC45B, UNC80, UNC93B1, UNG, UPB1, UPF3B, UPK2, UPK3A, UQCC1, UQCC2, UQCC3, UQCR10, UQCR11, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ, UROC1, UROD, UROS, USB1, USF1, USF2, USH1C, USH1G, USH2A, USP18, USP27X, USP8, USP9X, UTP14A, UTP4, UTRN, UVRAG, UVSSA, VAC14, VAMP1, VAMP7*, VANGL1, VANGL2, VAPB, VARS, VARS2, VAX1, VCAN, VCL, VCP, VDAC1, VDR, VEGFA, VEGFC, VHL, VIM, VIP, VIPAS39, VKORC1, VLDLR, VMA21, VNN2, VPS11, VPS13A, VPS13B, VPS13C, VPS33A, VPS33B, VPS35, VPS37A, VPS45, VPS53, VPS54, VRK1, VSIG2, VSNL1, VSX1, VSX2, VWA3B, VWF, WAC, WARS2, WAS, WDPCP, WDR1, WDR11, WDR13, WDR19, WDR27, WDR34, WDR35, WDR36, WDR45, WDR45B, WDR48, WDR60, WDR62, WDR66, WDR72, WDR73, WDR81, WDR92, WFS1, WHRN, WHSC1, WIF1, WIPF1, WISP3, WNK1, WNK3, WNK4, WNT1, WNT10A, WNT10B, WNT3, WNT3A, WNT4, WNT5A, WNT7A, WRAP53, WRN, WT1, WWC1, WWC3, WWOX, WWTR1, XBP1, XDH, XIAP, XIST, XK, XKRX, XPA, XPC, XPNPEP2, XPNPEP3, XPR1, XRCC2, XRCC3, XRCC4, XYLT1, XYLT2, YAP1, YARS, YARS2, YME1L1, YWHAE, YY1, ZAP70, ZBBX, ZBTB16, ZBTB18, ZBTB20, ZBTB24, ZBTB40, ZBTB42, ZC3H14, ZC4H2, ZCCHC12, ZCCHC8, ZDHHC15, ZDHHC9, ZEB1, ZEB2, ZFAT, ZFHX3, ZFHX4, ZFP57, ZFPM2, ZFR, ZFX, ZFYVE26, ZFYVE27, ZIC1, ZIC2, ZIC3, ZIC4, ZIC5, ZIM2, ZMPSTE24, ZMYM3, ZMYM6, ZMYND10, ZMYND11, ZMYND12, ZMYND15, ZNF141, ZNF148, ZNF197, ZNF335, ZNF365, ZNF408, ZNF41, ZNF423, ZNF425, ZNF469, ZNF513, ZNF526, ZNF592, ZNF599, ZNF644, ZNF674, ZNF687, ZNF711, ZNF713, ZNF750, ZNF778, ZNF81, ZP1, ZSWIM6