Тест 181.
Секвениране на пълен екзом (WES), не включва анализ и интерпретация

Характеристика на теста: (включва 19 369 гени)

Основание за насочване: 

Подходящи за този панел са и пациенти, при които не са открити патогенни варианти след директно и/или новогенерационно секвениране на гени/генни райони, включени в по-тeсните секвенционни панели.

Интерпретиране на резултатите:

  • Установяването на точкови мутации и малки делеции/инсерции в гените от панела ще позволи поставянето на генетична диагноза.

  • Наличие на големи делеции и инсерции не може да бъде установено с този метод. За установяването на такива се препоръчва комбинация с подходящ анализ за CNV (MLPA, aCGH).

  • Генетичният консултант ще интерпретира и отговори на всички въпроси относно резултата Ви.

Метод: Новогенерационно секвениране

Методът включва двупосочно ДНК секвениране на всички кодиращи екзони и интрон-екзонни граници на прицелните гени. Лабораторията предлага Сангер-секвениране на единичен екзон или двойка екзони при родственици на пациента за определяне на носителския статус в случаите, когато мутацията е известна (Тест № 182).

Чувствителност на метода: > 98%; зависи от съдържанието на GC и АТ, както и от наличието на сегментно дуплицирани гени.

Какво включва тестът? 

  • Изолиране на ДНК и съхраняване на пробата.

  • Паралелно секвениране на прицелните гени.

  • Биоинформатичен анализ на секвенционните данни. За всеки пациент се анализират само данните за гена(ите) от интерес.

  • Оформяне на писмен резултат от генетичния тест.

  • Диагностична интерпретация на резултатите и генетично консултиране.

Биологичния материал: Венозна кръв или ДНК

За повече информация, моля прочете внимателно „Изисквания към биологичния материал и информация за транспортиране“.


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CYP46A1, CYP4A11, CYP4A22, CYP4B1, CYP4F12, CYP4F2, CYP4F22, CYP4F3, CYP7A1, CYSLTR1, CYSLTR2, DAOA, DAPK1, DARC, DAZ1, DAZ2, DAZ3, DAZL, DBH, DBI, DCAF13, DCC, DCK, DCLK1, DCN, DCP1B, DCTD, DCXR, DDAH1, DDAH2, DDR1, DDX11, DDX20, DDX25, DDX39B, DDX3Y, DDX5, DDX53, DDX58, DEFB1, DEFB126, DEFB4A, DGAT1, DGCR14, DGCR2, DGCR5, DGCR6, DGCR8, DGKD, DHH, DHRS4L1, DHX16, DHX36, DHX37, DIAPH2, DIO1, DIO2, DIP2A, DIP2C, DIRC2, DISC1, DISP1, DKK2, DKK3, DLG5, DLGAP3, DLL1, DLX3, DLX6, DMBT1, DMC1, DMRT1, DMXL1, DNAAF1, DNAAF2, DNAAF3, DNAH11, DNAH5, DNAH9, DNAI1, DNAI2, DNAJA4, DNAL1, DNASE1, DNASE1L3, DNASE2, DND1, DNMT3L, DOC2A, DOCK3, DOCK9, DPY19L2, DPYSL2, DRD1, DRD2, DRD3, DRD4, DRD5, DROSHA, DRP2, DSC3, DSCAM, DSCR8, DSG1, DSG4, DTNBP1, DUSP23, DUX4, DXO, DYX1C1, EBAG9, ECI1, ECM2, ECSIT, EDA2R, EDAR, EDARADD, EDN1, EDN2, EEF1B2, EEF2K, EFCAB5, EFR3A, EGLN1, EGR3, EHD2, EHMT2, EIF3H, EIF4E, ELANE, ELAVL2, ELF4, ELK1, ELP2, EMC4, EME1, EMG1, EN2, ENAM, ENO1, ENO3, ENSA, EPAS1, EPB41, EPB42, EPC2, EPHA2, EPHA3, EPHA5, EPHA7, EPHB6, EPHX1, EPHX2, EPO, EPOR, EPX, ERAP1, ERAP2, ERCC1, ERMAP, ESAM, ESR1, ESR2, ESRRG, ETNPPL, EVI5, EXO1, EXO5, EXOC4, EXTL3, F10, F11, F12, F13A1, F13B, F2, F2R, F2RL1, F3, F5, F7, FAAH, FABP1, FABP2, FABP3, FABP4, FABP6, FABP7, FADS2, FAM120A, FAM205A, FAM58A, FAM83H, FAM8A1, FAM91A1, FASLG, FASN, FBLIM1, FBLN1, FBN3, FBXL6, FBXO10, FBXO18, FBXW11, FBXW4, FCAR, FCER1A, FCER2, FCGR1A, FCGR2A, FCGR2B, FCGR3A, FCGR3B, FCGRT, FCN2, FCN3, FCRL3, FDFT1, FECH, FEM1A, FEN1, FERMT1, FEV, FEZF2, FFAR1, FFAR4, FGB, FGD3, FGF1, FGF2, FGF20, FGF9, FGFBP1, FGFR4, FGFRL1, FGG, FIGLA, FIP1L1, FKBP5, FKBP6, FKBPL, FLG, FLT1, FLT4, FMN1, FMO1, FMO2, FMO3, FMO4, FMO5, FMO6P, FN3K, FOLH1, FOXA3, FOXC2, FOXD3, FOXD4, FOXF1, FOXF2, FPGS, FPR1, FPR2, FRA10AC1, FREM3, FRG1, FRK, FRMD6, FRMD7, FRY, FRZB, FSCB, FSHB, FSHR, FTCD, FTH1, FTHL17, FURIN, FUT1, FUT2, FUT3, FUT6, FUT7, FUT8, FUZ, FXYD6, FYCO1, FZD1, FZD3, FZD6, FZD9, G6PC2, GAB2, GAD2, GADD45B, GAK, GAL3ST3, GALNS, GALNT12, GALNT18, GALNT2, GALNT9, GALNTL5, GALP, GAP43, GAS1, GAS2L2, GAS6, GBA3, GBGT1, GC, GCGR, GCKR, GCLC, GCLM, GCNT2, GDF15, GDF3, GDF5, GDF9, GEMIN2, GEMIN4, GFI1, GFI1B, GFPT1, GFPT2, GFRA1, GGH, GGT5, GH2, GHRH, GHRL, GIF, GIMAP8, GIP, GIPR, GIT1, GJA3, GJA4, GJA5, GJA8, GJC3, GLCCI1, GLI1, GLMN, GLO1, GLP1R, GLS, GLTSCR1, GLUD2, GMIP, GNA14, GNAI2, GNAS-AS1, GNB1L, GNB3, GNB5, GNMT, GNRH1, GOLGA3, GOLGA5, GON4L, GOT1, GP1BA, GP1BB, GP2, GP6, GP9, GPAM, GPANK1, GPATCH8, GPBAR1, GPC4, GPC6, GPD1, GPD1L, GPD2, GPI, GPIHBP1, GPR1, GPR12, GPR139, GPR143, GPR33, GPR68, GPS1, GPT, GPX1, GPX4, GRB10, GREM1, GRID1, GRIK1, GRIK3, GRIK4, GRIN3A, GRK4, GRK5, GRM3, GRM5, GRM7, GRM8, GSC, GSDMA, GSDMB, GSE1, GSN, GSR, GSTA1, GSTA2, GSTA3, GSTK1, GSTM3, GSTM4, GSTO1, GSTO2, GSTT2, GSTT2B, GSTZ1, GTDC2, GTF2E1, GTF2H1, GTF2IRD1, GTF2IRD2, GUCY2C, GYG1, GYLTL1B, GYPA, GYPB, GYPC, GYPE, GZMB, H19, H2BFWT, H6PD, HABP2, HAND2, HAS1, HAVCR1, HBA2, HBD, HBE1, HBEGF, HBG1, HBG2, HBM, HBS1L, HBZ, HCK, HCLS1, HCP5, HCRT, HCRTR1, HCRTR2, HDAC9, HDC, HDLBP, HDX, HEATR2, HELQ, HES6, HES7, HEY1, HGD, HHEX, HHIP, HIF1A, HIF1AN, HIGD2A, HIST1H2AE, HIST3H3, HK2, HLA-A, HLA-B, HLA-C, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DPB2, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-E, HLA-G, HLX, HMGA1, HMGA2, HMGCR, HMHA1, HMOX1, HMOX2, HMSD, HMX1, HMX2, HNMT, HNRNPH3, HOXA10, HOXA11, HOXA13, HOXA2, HOXA4, HOXB6, HOXD13, HOXD4, HP, HPGD, HPS1, HPS3, HPS4, HPS5, HPS6, HR, HRC, HRG, HRH2, HRH3, HS1BP3, HS6ST1, HSD11B1, HSD17B1, HSD17B2, HSD3B1, HSD3B7, HSF4, HSFY1, HSN2, HSP90AA1, HSP90B1, HSPA1A, HSPA1B, HSPA1L, HSPA5, HSPA8, HSPA9, HSPB6, HSPB7, HTN3, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR3C, HTR3E, HTR5A, HTR6, HTR7, HUS1B, HVCN1, HYDIN, HYLS1, HYMAI, IAPP, IBSP, ICAM1, ICAM4, ICAM5, ICK, ID3, IDE, IDO1, IFI30, IFI44L, IFITM3, IFNA10, IFNA17, IFNA2, IFNAR1, IFNAR2, IFNG, IFNL3, IFRD1, IGF2R, IGFALS, IGFBP1, IGFBP3, IGFBP5, IGFBP7, IGHA1, IGHG2, IGHM, IGKV, IGLL1, IHH, IKBIP, IL10, IL10RA, IL10RB, IL11RA, IL12A, IL12RB2, IL13, IL16, IL17A, IL17F, IL17RA, IL17RB, IL17REL, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1RL1, IL2, IL20RA, IL20RB, IL21, IL21R, IL23R, IL2RA, IL3, IL31RA, IL36RN, IL4R, IL5, IL6, IL6R, IL7, IL8, IL9, IL9R, IMMT, IMPA2, IMPAD1, IMPDH2, INHA, INMT, INSIG1, INSIG2, INSL3, INSL6, IQGAP1, IQGAP2, IQGAP3, IRAK1, IRAK3, IRAK4, IRF2, IRF4, IRF5, IRF6, IRF7, IRF8, IRGM, IRS1, IRS2, IRX4, ISL1, ISYNA1, ITCH, ITGA11, ITGA2, ITGA2B, ITGA4, ITGA9, ITGAE, ITGAM, ITGB2, ITGB3, ITIH1, ITIH3, ITIH4, ITIH6, ITK, ITPKC, ITPR3, ITSN2, JAG2, JMJD1C, JPH3, JUN, KALRN, KCNA3, KCNAB2, KCNE1L, KCNE2, KCNE3, KCNE4, KCNIP4, KCNJ15, KCNJ18, KCNJ3, KCNJ5, KCNJ6, KCNJ8, KCNJ9, KCNK6, KCNMB1, KCNMB3, KCNN3, KCNS1, KCNS3, KDM4C, KDM5A, KDM5D, KDM6B, KDR, KEL, KERA, KHDC3L, KHK, KIAA0100, KIAA0232, KIAA0319, KIAA0513, KIAA1033, KIAA1377, KIAA1432, KIAA1462, KIF17, KIF18A, KIF22, KIF5B, KIF6, KIFAP3, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR3DL2, KISS1, KISS1R, KL, KLB, KLF1, KLF10, KLF11, KLF7, KLHDC8B, KLHL10, KLHL9, KLK1, KLK12, KLK15, KLK4, KLK7, KLKB1, KLRK1, KMT2C, KMT2E, KNG1, KPNA1, KRT1, KRT10, KRT12, KRT13, KRT14, KRT16, KRT17, KRT18, KRT2, KRT3, KRT31, KRT37, KRT38, KRT4, KRT5, KRT6A, KRT6B, KRT6C, KRT74, KRT75, KRT81, KRT83, KRT85, KRT86, KRT9, KRTAP1-1, KYNU, L3MBTL1, LAMC1, LAMTOR2, LBP, LCAT, LCE3B, LCE3C, LCE5A, LCN10, LCT, LDHA, LDHB, LDLRAD4, LEMD3, LEP, LEPREL1, LETM1, LFNG, LGALS13, LGALS2, LGALS3, LHB, LHX1, LHX8, LIF, LIG1, LIG3, LILRA3, LIM2, LIMK1, LIN28A, LIN28B, LIPA, LIPC, LIPG, LIPH, LIPI, LIPN, LLGL1, LMAN1, LMBR1, LMF1, LMTK3, LNX2, LOC344967, LOR, LOXL2, LPA, LPAR1, LPAR6, LPIN1, LPIN2, LPIN3, LPL, LPP, LRCH1, LRFN5, LRP1, LRP4, LRP6, LRP8, LRPAP1, LRRC4, LRRC6, LRRC8A, LTA, LTBP1, LTBP3, LTC4S, LTF, LTK, LTN1, LUM, LY96, LYN, LYZ, LZTS1, MACROD2, MAD1L1, MAD2L1, MADD, MAF, MAFB, MAGEE2, MAGEL2, MAGT1, MAMLD1, MAN1A2, MAN1B1, MAOB, MAP2, MAP2K3, MAP2K4, MAP3K1, MAP3K15, MAP4K5, MAP6, MAP7D3, MAPK8IP1, MASP2, MAST4, MASTL, MAVS, MBD1, MBD3, MBD4, MBL2, MC1R, MC3R, MC4R, MCF2L2, MCFD2, MCHR1, MCL1, MCM5, MCM6, MDH1, MDM2, MDM4, MDN1, MED13, MED25, MEF2A, MEGF11, MEIS1, MEP1B, MESDC2, MESP2, MEST, MFF, MFGE8, MFI2, MGAT1, MGAT4C, MGEA5, MGLL, MGMT, MGST2, MGST3, MIA3, MIAT, MICA, MICB, MIF, MIIP, MINPP1, MIP, MIPOL1, MIR106B, MIR124-1, MIR125A, MIR126, MIR140, MIR146A, MIR16-1, MIR17, MIR17HG, MIR184, MIR191, MIR196A2, MIR206, MIR24-1, MIR27A, MIR2861, MIR30C1, MIR34B, MIR499A, MIR502, MIR510, MIR890, MIR892B, MIR934, MIRLET7E, MKL1, MKRN3, MLH3, MLXIPL, MMEL1, MMP1, MMP10, MMP12, MMP13, MMP14, MMP2, MMP20, MMP3, MMP7, MMP8, MMP9, MNX1, MOCOS, MOG, MOK, MPG, MPHOSPH8, MPP3, MPP4, MPP6, MPP7, MPST, MRC1, MRPL48, MRRF, MS4A1, MS4A12, MS4A2, MS4A3, MS4A6E, MSH3, MSH4, MSH5, MSMO1, MST1, MST1R, MSTN, MSX1, MT1A, MT2A, MTCH2, MTHFD1, MTHFD1L, MTHFS, MTMR14, MTMR9, MTNR1A, MTNR1B, MTUS1, MUC13, MUC2, MUC3A, MUC4, MUC5B, MUC6, MUC7, MURC, MUSK, MX1, MYB, MYBL2, MYBPC1, MYCL, MYH13, MYH15, MYH2, MYH3, MYH8, MYLIP, MYO18B, MYO5B, MYO7B, MYO9B, MYOCD, MYOZ2, MYT1, MYT1L, NAGPA, NAIP, NAMPT, NAPRT1, NAT1, NAT8L, NAV2, NBAS, NBEA, NBEAL2, NBPF1, NCALD, NCAM1, NCAN, NCAPD2, NCF1, NCF2, NCF4, NCKAP1, NCOA1, NCOA3, NCR3, NCS1, NCSTN, NDN, NDOR1, NDUFA13, NDUFA4, NDUFA6, NDUFA8, NDUFAF7, NDUFB1, NDUFB6, NDUFC2, NDUFV3, NEDD9, NEFM, NEIL2, NELFA, NELL1, NEU2, NEUROD1, NFATC4, NFE2L2, NFIA, NFKB1, NFKBIL1, NGFR, NID1, NINJ1, NIPAL4, NIPSNAP1, NIPSNAP3A, NKAIN2, NKX2-3, NLGN1, NLGN2, NLGN4Y, NLRP1, NLRP12, NLRP14, NLRP2, NLRP7, NLRX1, NMB, NME1, NME8, NMT2, NMU, NOBOX, NOD1, NOD2, NOG, NOP10, NOS1, NOS1AP, NOS2, NOTCH4, NPAP1, NPAS2, NPAS3, NPAT, NPC1L1, NPFFR2, NPL, NPPB, NPPC, NPR1, NPR2, NPR3, NPSR1, NPTN, NPY, NPY1R, NPY2R, NQO1, NQO2, NR0B1, NR0B2, NR1H2, NR1H3, NR1H4, NR1I2, NR1I3, NR2E1, NR3C1, NR4A2, NRG1, NRG3, NRIP1, NRP2, NRTN, NRXN3, NSMF, NSUN7, NT5C1B, NT5C3A, NTF3, NTHL1, NTRK2, NTRK3, NUAK1, NUDC, NUDT1, NUDT6, NUMBL, NUP155, NXF3, NXNL1, OAS1, OAS2, OAZ1, OBSCN, OBSL1, OCA2, ODC1, OGG1, OLFM2, OLR1, OMG, OPCML, OPN4, OPRD1, OPRK1, OPRL1, OPRM1, OPTC, OR13G1, OR7D4, ORMDL3, OSMR, OSR1, OVGP1, OXTR, P2RX1, P2RX4, P2RX5, P2RX7, P2RY11, P2RY12, P2RY4, PABPC4L, PABPN1, PACRG, PAFAH1B3, PAK7, PALLD, PAPD7, PAPSS2, PARD3B, PARD6A, PARL, PARP1, PARP2, PASK, PAWR, PAX1, PAX4, PAX7, PAX9, PCDH11X, PCDH18, PCDHA10, PCDHA13, PCDHB4, PCK1, PCM1, PCMT1, PCOLCE, PCSK1, PCSK2, PCSK9, PDCD1, PDCD5, PDE4B, PDE7B, PDGFC, PDPK1, PDX1, PEAR1, PECAM1, PECR, PEMT, PENK, PER1, PER2, PER3, PFAS, PGAM1, PGAM5, PGBD1, PGC, PGD, PGR, PGRMC1, PHB, PHF11, PHF3, PHIP, PHLDA2, PHLPP2, PHOX2A, PI3, PICK1, PIEZO2, PIF1, PIGR, PIK3C2G, PIK3C3, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R4, PIKFYVE, PIN1, PIP4K2A, PIP5K1C, PITX1, PIWIL3, PKD1L1, PKM, PKN3, PKP1, PLA2G10, PLA2G2A, PLA2G2D, PLA2G4A, PLA2G4C, PLA2G7, PLAGL1, PLAT, PLAUR, PLCB4, PLCD1, PLCG2, PLCZ1, PLD2, PLEKHG4, PLIN4, PLP2, PLTP, PLXND1, PMAIP1, PMPCA, PMS2P3, PNMT, PNPLA1, PNPLA3, POF1B, POLB, POLE2, POLH, POLL, POLR2E, POLR2M, POLRMT, POMP, PON2, PON3, POP1, POU5F1, POU5F1B, POU6F2, PPARA, PPARD, PPARGC1A, PPARGC1B, PPAT, PPIA, PPIG, PPM1D, PPP1R1A, PPP1R3A, PPP1R3C, PPP2R1A, PPP2R2C, PRB1, PRB3, PRB4, PRCP, PRDM2, PRDM9, PREPL, PRG4, PRKAA2, PRKACA, PRKAG3, PRKCB, PRKCH, PRKCSH, PRKD3, PRKDC, PRL, PRLHR, PRLR, PRM1, PRM2, PRMT10, PRMT3, PRMT7, PRND, PROC, PROCR, PROK1, PROK2, PROKR1, PROS1, PROZ, PRRC2A, PRRX1, PRSS1, PRSS2, PRSS3P2, PRSS56, PRSS8, PRY, PRY2, PSCA, PSMA6, PSMB8, PSMB9, PSMC3IP, PSMD7, PSPN, PSTPIP1, PTAFR, PTCD1, PTCH2, PTCHD3, PTCSC3, PTGDR, PTGDR2, PTGDS, PTGER2, PTGER4, PTGES2, PTGIR, PTGIS, PTGS1, PTGS2, PTHLH, PTK7, PTPN1, ZPBP2, BTNL2, CCHCR1, CYP3A4, FGF10, FOXA1, GGCX, GSPT1, GSTM1, GSTT1, HIP1, IL4, KLF5, KLF6, KLK3, KRT8, LEPR, MLPH, MSMB, MSR1, NKX3-1, PDLIM5, PON1, RNASEL, SLC22A3, TERT, THADA, ZFHX3, ALOX12, ARHGEF12, AXL, BAX, BCL2, CBLB, CSF3R, ETS1, FBXW7, FLT3, GATA1, IL7R, IRF1, JAK2, MLLT3, MYC, NPM1, PAX5, PML, RGS2, STAT3, TAL1, ADNP, AHCY, ALDOA, ALX4, AVPR1A, BDNF, CACNG2, CASC5, CC2D1A, CDC6, CDH15, CDON, CDT1, CENPJ, CEP135, CEP63, COLEC11, CRADD, CTNNB1, DDOST, DIP2B, DMPK, DOCK4, DPP10, DPP6, EOMES, EP300, EPB41L1, ERLIN2, EXOSC3, FAAH2, FLVCR2, FOXP1, FOXP2, GRPR, HERC2, HOXD10, HYAL1, IGF1R, IMMP2L, IRX5, KAT6B, KATNAL2, KCND2, KCNH2, KCNJ2, KCNK9, KCTD13, KIAA1279, KIF21A, KIRREL3, LINS, LMBRD1, MED23, MPLKIP, MYCN, NEGR1, NFIX, NHP2, NIPBL, NODAL, ORC1, ORC4, ORC6, PDE4D, PEPD, PGAM2, PGM1, PHKB, PHKG2, PIP5K1B, PVRL1, RAD21, RBBP8, RBM28, RFX6, RNF135, SATB2, SCN4B, SHANK2, SLC6A4, SLC7A7, SLC9A9, SMOC1, SOBP, SOX5, SRCAP, STAT5B, STK3, TAF2, TDGF1, TECR, TGIF1, TINF2, TMCO1, TPH2, TTC37, TTI2, TUBGCP4, TUBGCP6, TWIST1, UROC1, VANGL1, ZBTB16, ZBTB24, ZC3H14, ZFP57, ZIC2, ZMYND11, ZNF335, ZNF507, ZNF526, ZNHIT6, ADAR, AIMP1, ALG13, ANK3, ARFGEF2, ATP2A2, B3GNT1, BRAT1, CCBE1, CHD2, CHD8, CNNM2, CNR2, CNTNAP2, COG5, COL4A2, CTC1, DNAJC5, DNM1, DOCK6, DYRK1A, EHMT1, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, FADD, FMN2, GLRA1, GLRB, GPR56, GRIN1, GRIN2B, HCN1, HDAC4, HEPACAM, HNRNPU, IER3IP1, ITPA, JAM3, KCTD7, KRIT1, LAMB1, LAMC3, MAGI2, MAPK10, MBD5, MFSD2A, MPDZ, NAGA, NDST1, NRXN1, PAFAH1B1, PDCD10, PIK3R2, PRICKLE1, PRICKLE2, ROGDI, SETD2, TYROBP, ADRA2B, CACNA1H, CASQ2, CHRNA2, CHRNA4, CHRNB2, CPA6, CRH, CSNK1D, ELP4, EPHB2, GABBR1, GABRA6, GABRD, GABRG1, GJD2, GPR55, HCN2, HTR1A, INPP4A, JRK, KCNK18, KCNMA1, KCNQ3, LGI1, RBFOX1, SCN10A, SCN2B, SCN3A, SGCE, SLC4A10, AASS, ABAT, ACSF3, ADK, AGA, ALG11, ARG1, ATIC, CTSA, GNS, GYS2, HMBS, KCNJ11, MTR, PCBD1, PFKM, PRODH, PTS, QDPR, SLC46A1, SUMF1, AMER1, GRIA3, HDAC8, IGBP1, IQSEC2, PHF6, PIGO, XK, ATCAY, ATP8A2, ATXN1, ATXN8OS, BEAN1, HTT, ITPR1, KCNC3, LAMA1, MRE11A, NOP56, PDYN, PIK3R5, PPP2R2B, PTF1A, RNF170, SPTBN2, TDP1, TGM6, TTBK2, ARHGEF10, DNAJB2, DST, LITAF, LRSAM1, MCM3AP, MTMR2, NDRG1, NEFL, RAB7A, SH3TC2, YARS, AP5Z1, ENTPD1, FAM134B, HSPB3, KIAA0196, NIPA1, RTN2, ZFYVE27, ABCA7, AKAP9, BLMH, HFE, HLA-DRB1, HLA-DRB5, MS4A6A, NOS3, PLAU, UNC5C, ADH1C, COMT, PDXK, RAB7L1, SLC30A10, SNCAIP, PSENEN, VPS35, DAO, LOXL1, NTF4, PITX3, RPS19, WDR36, ADIPOR1, ACBD5, ARMS2, C2, FSCN2, FZD4, GDF6, GUCA1B, OPN1LW, OPN1MW, OPN1SW, RP9, TEAD1, TSPAN12, UNC119, ZNF513, ANKH, ATP2B2, CATSPER2, CCDC50, CEACAM16, CHSY1, CLDN14, COCH, CRYM, DCDC2, DFNA5, DFNB59, DIAPH1, DIAPH3, DLX5, DSPP, ECE1, EDNRA, ESPN, ESRRB, FAS, FGF3, FOXI1, GIPC3, GJB4, GJB6, GPSM2, GRHL2, GRXCR1, GSTP1, HAL, HGF, HOMER2, ILDR1, KCNE1, KCNQ4, KIAA1199, KITLG, LHFPL5, LOXHD1, LRTOMT, MARVELD2, MASP1, MGP, MIR182, MIR96, MITF, MSRB3, MTAP, MYH14, MYO15A, MYO1A, MYO1C, MYO1F, MYO3A, MYO6, OTOA, OTOF, OTOR, PAX3, POLR1D, POU3F4, POU4F3, PTPRQ, SEMA3E, SERPINB6, SLC13A2, SLC17A8, SLC26A5, SLC29A3, SLC52A3, SMPX, SNAI2, SPINK5, STRC, TCF21, TCOF1, TECTA, TFB1M, TFCP2, TJP2, TMC1, TMIE, TMPRSS3, TMPRSS5, TNC, TPRN, TRIOBP, TYR, ADCY10, AGT, AGTR1, AGXT, APOL1, APRT, AQP2, ATP6V0A1, ATP6V0A4, BICC1, BMP4, C1QA, C1QB, C1QC, CD46, CFHR1, CFHR3, CFHR5, CHD1L, CYP11B2, CYP24A1, EGF, FAM20A, FN1, FREM1, FXYD2, GDNF, GLIS2, GRHPR, GRIP1, GSK3B, HNF4A, HPSE2, KAL1, LAMA5, MUC1, NEIL1, NEK8, NOTCH2, NR3C2, PHF2, PKD1, REN, ROBO2, ROR2, SGK1, SIX2, SLC12A3, SLC22A12, SLC2A2, SLC2A9, SLC3A1, SLC4A1, SLC7A9, SLC9A3R1, SOX17, STK39, SYNPO, THBD, UPK3A, VIPAS39, WNT4, XDH, CYP2R1, FGF8, FOXA2, GALNT3, GCM2, LIPE, MC2R, MCM4, NT5E, PDE11A, PDE8B, PLIN1, PPARG, PROKR2, TBX19, ABCG5, ABCG8, ACTA1, ACTC1, ACTN2, ACVR2B, ACVRL1, ANKRD1, APOB, ATP2A1, BAG3, BMPR1B, BMPR2, CALR3, CAPN3, CAV3, CFL2, CHRM2, CNTN1, CRELD1, CRYAB, CSRP3, CTF1, CTNNA3, DES, DNAJB6, DSC2, DSG2, DTNA, DYSF, EMD, FHL1, FHL2, FLNC, GATA4, GATAD1, GDF1, HAND1, ILK, JPH2, JUP, KBTBD13, KCNA5, LAMA4, LDB3, LDLR, LDLRAP1, LEFTY2, MED13L, MEGF10, MEIS2, MYBPC3, MYF6, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOM1, MYOT, MYPN, NEBL, NEXN, NKX2-5, NKX2-6, NPPA, PDLIM3, PKP2, PLN, PRKAG2, RASA1, RBM20, RYR1, RYR2, SGCB, SGCD, SGCG, SMAD6, SMAD9, SUN2, SYNE2, TBX5, TCAP, TMEM43, TMPO, TNNC1, TNNI3, TNNT1, TNNT2, TPM1, TPM2, TPM3, TTN, TXNRD2, ZFPM2, ACAD8, AGK, AK2, ALAS2, ALDH6A1, ATP5E, BCAT2, COX4I2, CYCS, DECR1, DHODH, DLAT, DMGDH, DNM1L, GFER, GLRX5, HMGCS2, ISCU, MCEE, MRPL3, NDUFB9, NFU1, PCK2, PDHB, PNPLA2, SARS2, SLC25A13, SLC25A3, SLC25A38, SLC25A4, UNG, YARS2, XYLT2, NFKBIA, VKORC1, ABCB1, NAT2, AKT1, ERBB2, FOXL2, GNAQ, ABCA12, ABCA3, ABCB11, ABCB4, ACADL, ADA, ALDOB, ANTXR2, ATP8B1, ATR, CASP10, CD19, CD247, CD3D, CD3E, CD3G, CD40LG, CFP, CFTR, CHRNA1, CHRND, CHRNG, CLDN1, COL17A1, COL7A1, CTSK, CYP11A1, CYP17A1, DCLRE1C, DLL3, DOK7, DYNC2H1, EDA, ERBB3, EVC, EVC2, F8, F9, FAH, FERMT3, FOXN1, FOXP3, G6PC, G6PD, GALK1, GLE1, HAMP, HBA1, HBB, HFE2, HSD17B3, HSD3B2, ICOS, IFNGR1, IFNGR2, IL12B, IL12RB1, IL1RN, IL2RG, LAMA3, LAMB3, LAMC2, LARGE, LHCGR, MEFV, MYD88, NDUFA7, NDUFS5, NEUROG3, NR5A1, NUP62, ORAI1, PKLR, PLG, POR, RAB23, RAG1, RAG2, SC5DL, SEPN1, SFTPB, SFTPC, SH2D1A, SMN1, SP110, STAT1, TGM1, TRIM37, TSPYL1, TYK2, UNC93B1, UROS, WAS, WNT10A, WNT3, WNT7A, XIAP, HOXB13, IGF2, ASXL1, CREBBP, SETBP1, AKT3, ANKRD11, ARID1A, ARID1B, ASPM, ATP10A, AUTS2, B3GALTL, CDK5RAP2, CEP152, CNTNAP5, CRBN, DEAF1, EFTUD2, EMX2, FGFR2, FTO, HACE1, IFIH1, KANSL1, KMT2D, LMNB2, MCPH1, MSX2, NDE1, OCLN, PCNT, PIGV, POGZ, POLR3A, POLR3B, SHANK3, SHH, SIX3, SMARCA2, SMARCA4, SMARCE1, SMC1A, SMC3, SNRPN, STIL, STRADA, SYNGAP1, TBL1XR1, TMEM165, TSEN2, TSEN34, TUBB3, WDR62, ZBTB18, GABRG3, MR1, NRXN2, PCDH9, SCN3B, SCN4A, SLC6A5, ADORA2A, ATP1A2, CACNA2D1, CCM2, CHRNA7, DLGAP2, ECM1, EFHC1, GABRA1, GABRA5, GABRB3, GABRG2, GABRR2, MED17, PIGM, PIGN, PLCB1, RAB18, RNASET2, SCN1B, SCN2A, SCN8A, SCN9A, SEPSECS, SLC6A1, SNIP1, SPTAN1, SRGAP2, STXBP1, TOR1A, TUBA8, TUBB2B, INS, ABCD4, COG4, GALE, MAT1A, POMC, PYGL, UPB1, ACY1, ADSL, AKT2, ASNS, COQ4, DHFR, DPYS, GLUL, GLYCTK, GM2A, GPHN, MTRR, PEX11B, PEX14, PEX16, PEX19, PEX3, PHGDH, PIGL, BCAP31, CCDC22, FRMPD4, KIAA2022, NLGN3, PHF8, PHKA1, PHKA2, PORCN, PTCHD1, RAB40AL, RBM10, TRIP12, TSPAN7, USP9X, ZCCHC12, ZDHHC15, ZNF804A, ZNF81, CLIC2, EFHC2, SYN1, CNKSR2, GSPT2, SRPX2, ANO10, CA8, CACNA1G, FGF14, KCND3, LMNB1, SYT14, ZNF592, ATXN10, CAMTA1, CCDC88C, CP, GOSR2, PNKP, WDR81, CACNB4, KCNA1, PRRT2, SLC1A3, CTDP1, SPTLC1, DYNC1H1, MME, CYP7B1, GAD1, KIF1A, SCP2, SPG21, AP4B1, AP4E1, AP4M1, ASAH1, VRK1, CCT5, HSPB1, HSPB8, MEF2C, FTL, ATP6AP2, ATXN3, PRPH, A2M, CLU, MPO, PICALM, SORL1, DNAJC6, EIF4G1, FBXO7, GIGYF2, PRKRA, SLC6A3, CHGB, ERBB4, CST3, CX3CR1, CANT1, PAX6, SBF2, LTBP2, MYOC, PRKCG, KIF11, ATXN7, MTTP, CDH3, RP1L1, TIMP3, ADAM9, ADAMTS18, CACNA2D4, CNNM4, GNAT2, GUCA1A, KCNV2, PDE6C, PDE6H, RAB28, RGS9, RGS9BP, RD3, CHM, CNGA1, CNGB1, DHDDS, EYS, FAM161A, IFT140, KLHL7, MAK, MFRP, NR2E3, NRL, PDE6A, PDE6G, PLA2G5, PRCD, PRPF3, PRPF6, PRPF8, RBP3, RBP4, RGR, ROM1, RP1, RP2, SNRNP200, TOPORS, GNAT1, GPR179, GRK1, GRM6, NYX, SLC24A1, TRPM1, AP1S1, HOXA1, IGF1, KCNQ1, ACTB, ACTG1, DCAF17, GJB1, CIB2, DFNB31, PCDH15, PDZD7, VCAN, GJB3, HNF1B, AVP, B9D1, C5orf42, CLCNKA, CLCNKB, NEDD4L, CCDC28B, ATP6V1B1, BSND, CD151, COL4A6, EYA1, SALL4, SIX1, SIX5, TFAP2A, ACTN4, C10orf2, CUBN, ITGA3, MYO1E, PTPRO, SMARCAL1, TRPC6, UMOD, AGPAT2, GLI3, PTH, POLD1, CUL3, KLHL3, PHEX, SLC34A1, SLC34A3, WNK4, GHR, DUOX2, DUOXA2, FOXE1, GLIS3, IRS4, IYD, PAX8, SECISBP2, TG, TRHR, GHRHR, GHSR, ABCC9, DAG1, FOXH1, GATA6, ITGA7, RAF1, SGCA, SHOC2, SOS1, SPRED1, TBX1, SYNE1, DNM2, EYA4, PPOX, YWHAE, AARS2, BOLA3, COA5, COX14, TACO1, ACADS, ACADSB, ALDH4A1, FBP1, GCK, L2HGDH, LIAS, MCCC1, MLYCD, MMADHC, FXN, KIF1B, TMEM126A, CISD2, DIABLO, SLC19A2, TRMU, HOGA1, MTO1, ANO5, ACTA2, ADAMTS10, B3GALT6, BMP1, C1R, C1S, COMP, DDR2, FKBP10, FLNB, GORAB, IFITM5, IFT122, IFT43, LOX, LTBP4, MATN3, NEK1, NKX3-2, PLEKHM1, PLOD2, PLOD3, PPIB, PRDM5, SERPINF1, SERPINH1, SHOX, SLC2A10, SMAD2, SNX10, SOX9, SP7, TNFRSF11A, TNFSF11, TRAPPC2, TRIP11, WDR35, CADM1, PPP2R1B, FGA, ITGA6, SRD5A2, JAK3, MPL, ALG8, AP3B1, ARHGEF6, B4GALT1, DNMT3B, EFNB1, G6PC3, GBE1, GTF2H5, GUSB, IKBKAP, LIG4, MCOLN1, MID1, NHEJ1, NSUN2, NTRK1, NXF5, PRSS12, RAPSN, SMPD1, SMS, SNAP29, STRA6, STX11, TAT, TUSC3, CTSD, DCX, DOCK8, EPM2A, FOXG1, GRIK2, MLC1, MYO5A, NEU1, NHLRC1, NPC1, NPC2, PPT1, PSAP, RAB27A, RNASEH2A, RNASEH2B, RNASEH2C, STXBP2, TCF4, UBR1, UNC13D, ABCC8, ACOX1, ALDH3A2, ALG1, ALG12, ALG2, ALG3, ALG6, ASL, DPYD, HPD, INSR, MMACHC, MOGS, MPDU1, PMM2, PNPO, SLC37A4, SUOX, AFF2, AP1S2, ARHGEF9, ATRX, CUL4B, FTSJ1, IL1RAPL1, KDM5C, PAK3, PCDH19, SYP, ZDHHC9, EGR2, PRX, UBA1, TLR3, ARSB, EDN3, EDNRB, SLC4A11, ADAMTS13, CLCN5, CLDN19, CTNS, CYP11B1, FREM2, HSD11B2, PKHD1, SCNN1A, SCNN1B, SCNN1G, VPS33B, AGPS, AIRE, FAM20C, GNRHR, TSHB, ZMPSTE24, CYP21A2, COL6A1, COL6A2, COL6A3, DSP, NEB, PLEC, STIM1, ZIC3, DGUOK, HADHA, HADHB, MRPS16, OXCT1, RMRP, SCO1, SLC22A5, TSFM, UQCRB, UQCRQ, CYLD, DIS3L2, EXT1, EXT2, FANCA, FANCB, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FLCN, HNF1A, RECQL4, RHBDF2, WRN, DNMT3A, CYP2C19, NTNG1, PDE10A, UNC80, COG6, SLC16A1, PNP, PSAT1, PSPH, KDM6A, PIGA, NAA10, KIAA0226, CACNA1A, GRM1, FMR1, NGF, AARS, AP4S1, ZFYVE26, FA2H, GFAP, CLCN2, GAN, VPS13A, WDR45, ATN1, SERPINI1, CR1, PDGFB, UCHL1, SNCA, SNCB, APP, PSEN2, TOMM40, ANG, PFN1, SOD1, VAPB, VEGFA, MTHFR, CYP1B1, PGK1, EFEMP1, HMCN1, TLR4, CNGA3, FLVCR1, C1QTNF5, IMPG2, CA4, CDHR1, CYP4V2, PITPNM3, RIMS1, SEMA4A, LCA5, LRAT, NMNAT1, SPATA7, TULP1, PRPF31, KCNJ13, CACNA1F, PDE6B, SAG, POLR1C, RAI1, SOX10, GRIN2A, TBC1D24, MANBA, NARS2, PEX6, ABHD5, NR2F1, HARS, B9D2, CLDN16, TRPM6, AVPR2, ARL13B, CEP41, TCTN1, TCTN2, TMEM138, TMEM216, ACE, CFI, SLC4A4, WDPCP, LZTFL1, NLRP3, SALL1, FOXC1, INF2, KANK1, CD2AP, LMX1B, MYH9, PAX2, GNPAT, MRAP, PNPLA6, PITX2, FGFR1, WNK1, GATA3, CDKN1B, FGF23, THRA, NKX2-1, SLC5A5, THRB, SLC26A4, TBL1X, TPO, LHX4, GH1, CBL, CACNA1C, CHKB, MAP2K1, MAP2K2, SCN5A, ENG, GYS1, DPM3, LAMP2, GNE, BIN1, MATR3, ISPD, JAG1, CAV1, HCN4, POLG2, SLC25A19, RARS2, SLC25A12, ATPAF2, C12orf65, CYB5R3, GATM, MCCC2, PUS1, D2HGDH, EARS2, FARS2, FOXRED1, GLUD1, NDUFA11, NDUFA12, NDUFA2, NDUFA9, SDHAF1, SLC19A3, HCCS, MAOA, GK, MTFMT, TTC19, PNKD, ACO2, ATL1, ABCB7, MTPAP, GARS, REEP1, HTRA2, LRRK2, PARK2, PARK7, PINK1, MFN2, IDH3B, OAT, HARS2, LARS2, KARS, XPNPEP3, COQ6, ELAC2, NOTCH1, B4GALT7, DYM, PYCR1, RIN2, COL4A1, NSDHL, LRP5, COL11A2, COL9A2, COL9A3, PKD2, TNXB, TTC21B, ADAMTS2, CHST14, COL12A1, COL3A1, COL5A1, COL5A2, ELN, FBN2, FKBP14, FOXE3, MYH11, MYLK, SLC39A13, SMAD3, TGFB2, TGFB3, RDX, PIK3CA, AR, CRLF1, DHCR24, ERCC8, ESCO2, FAM126A, HAX1, NAGLU, ST3GAL3, TRAPPC9, TUBA1A, ST3GAL5, DDC, DPAGT1, GNPTAB, IDUA, MPI, PYGM, ALG9, ARSA, ASPA, CLN8, COG1, COG7, COG8, FUCA1, MGAT2, MOCS1, MOCS2, PAH, PEX10, PEX12, PEX13, PEX5, RFT1, SGSH, SLC35A1, SLC35C1, ACSL4, ARX, BRWD3, DKC1, DLG3, FGD1, GDI1, HUWE1, IKBKG, NHS, NLGN4X, RPL10, SHROOM4, UBE2A, UPF3B, ZNF674, ZNF711, MECP2, IDS, VLDLR, CLN6, CSTB, HEXB, TPP1, ALDH5A1, GSS, OPHN1, MPZ, SLC12A6, FGD4, GJC2, RAB3GAP1, ABCD1, IGHMBP2, PLEKHG5, MFSD8, HGSNAT, PMP22, CDH23, USH1G, GJB2, FRAS1, ASS1, AGTR2, HPRT1, INVS, NPHP4, COL4A3, COL4A4, COL4A5, SLC12A1, ITGB4, LAMB2, PLCE1, CYP27B1, DMP1, ENPP1, BTK, FKRP, GAA, FKTN, AGL, DOLK, MTM1, ACAT1, MPV17, MUT, TK2, TYMP, COX6B1, GFM1, SAMHD1, ACADM, AMT, BCKDHA, BCKDHB, ETFA, ETFB, ETFDH, ETHE1, GCDH, HLCS, HMGCL, IVD, MMAA, NAGS, PCCA, PCCB, SLC25A20, HSD17B10, APTX, GDAP1, STAR, TAZ, ADAMTSL2, ALPL, CLCN7, HSPG2, IFT80, LEPRE1, LIFR, OSTM1, PLOD1, PTH1R, SLC26A2, SLC35D1, TCIRG1, TNFRSF11B, ZNF469, DDB2, FANCC, SBDS, XPC, RAD51C, RAD51D, CEBPA, GATA2, RUNX1, ALK, PHOX2B, SUFU, CEP57, FANCD2, SLX4, AIP, CDK4, SPR, TAF1, GCH1, TBP, PRNP, PSEN1, GRN, MAPT, SETX, NEFH, ATXN2, CHMP2B, SIGMAR1, UBQLN2, OPTN, ITM2B, CNGB3, RAX2, GNPTG, PEX2, RLBP1, RDH12, AIPL1, MERTK, RPGRIP1, CABP4, RS1, KCNJ10, DNMT1, ABHD12, KIF7, APOE, TMEM237, C3, CFB, BBS10, BBS12, BBS5, BBS7, BBS9, MKKS, CACNA1D, SCARB2, GNAS, TSHR, PTPN11, TTR, GJA1, SQSTM1, TPK1, NDUFAF1, NDUFAF3, NDUFAF5, NDUFB3, NDUFS1, NDUFV2, NDUFAF6, SPAST, HSPD1, DARS2, AFG3L2, MARS2, SPG7, HK1, AIFM1, TMEM70, ALDH18A1, TRPV4, ACVR1, COL18A1, FGFR3, COL11A1, COL2A1, COL9A1, ABCC6, FBN1, TGFBR1, TGFBR2, FLNA, IDH1, MET, GALT, ALDH7A1, CDKL5, ZNF41, TSEN54, RELN, SRD5A3, CLN5, FOLR1, CASK, SLC9A6, LYST, RAB3GAP2, ZEB2, GLB1, GALC, PQBP1, PLP1, HEXA, RAB39B, ALS2, VPS13B, TREX1, MVK, TTPA, MAN2B1, HSD17B4, PEX26, RPS6KA3, CLRN1, USH1C, SLC17A5, KCNJ1, OCRL, RPGRIP1L, NPHP3, IQCB1, LRP2, NPHS1, NPHS2, TBCE, SOX3, VDR, LAMA2, POMGNT1, POMT2, DPM1, DMD, GLA, LMNA, MRPS22, TUFM, SLC25A22, DLD, FASTKD2, MMAB, COX10, COX15, CPS1, CPT1A, DBT, GAMT, GCSH, GLDC, HADH, PC, PDHX, PDP1, OTC, PDHA1, SLC6A8, AMACR, ADCK3, SCO2, SLC25A15, OPA3, SUCLA2, BTD, TMEM127, ACADVL, MBTPS2, EIF2AK3, ARSE, CBS, COL1A1, COL1A2, CRTAP, EFEMP2, UBE3A, HIBCH, XPA, BAP1, DICER1, PMS1, EZH2, PTCH1, SMARCB1, NF2, CDKN1C, MAX, CDC73, SCN1A, KCNQ2, SPG11, ATP13A2, ATP1A3, SLC20A2, NOTCH3, TREM2, FIG4, C9orf72, TARDBP, GUCY2D, IMPDH1, RPE65, CERKL, PROM1, RHO, CC2D2A, BBS4, BBS2, SDCCAG8, CFH, CASR, GLI2, SOX2, TRIM32, NDUFA10, NUBPL, NDUFS2, WWOX, KIF5A, SPG20, SLC33A1, WDR19, EBP, SKI, KRAS, NRAS, SIL1, AAAS, PLA2G6, GPR98, NDP, MYO7A, PEX1, DHCR7, TMEM67, ATP7B, BCOR, POMT1, ACAD9, NDUFAF2, NDUFAF4, NDUFS3, NDUFS6, LRPPRC, PDSS1, COQ9, NDUFS7, NDUFS8, SURF1, AUH, CYP27A1, RRM2B, SUCLG1, DNAJC19, CPT2, ATP6V0A2, LBR, MED12, ERCC4, GPC3, BRIP1, TSC1, TSC2, HRAS, SDHAF2, SDHB, SDHC, CSF1R, FUS, DCTN1, ELOVL4, HTRA1, CRB1, RDH5, PHYH, RPGR, ARL6, BBS1, TTC8, BSCL2, VCP, CHD7, WFS1, SDHA, IDH2, PDGFRA, BRAF, GBA, CLN3, PRPS1, USH2A, L1CAM, AHI1, OFD1, NPHP1, SLC16A2, LHX3, PROP1, NDUFA1, NDUFS4, SACS, PANK2, BCS1L, PDSS2, CA2, ATP7A, BLM, ERCC5, FH, BMPR1A, CDH1, CHEK2, STK11, EPCAM, PALB2, WT1, VHL, SDHD, CDKN2A, SLC2A1, ABCA4, CRX, BEST1, EGFR, TH, MKS1, POU1F1, ALMS1, NDUFV1, ERCC6, TIMM8A, COQ2, PRF1, ERCC2, ERCC3, MUTYH, PMS2, BUB1B, PRPH2, OTX2, OPA1, CEP290, HESX1, POLG, FBLN5, NBN, NSD1, NF1, RB1, KIT, APC, MEN1, PRKAR1A, PEX7, BRCA1, BRCA2, SMAD4, ATM, MSH6, RET, PTEN, MLH1, MSH2, TP53
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40 работни дни